Influence of oral administration of kukoamine A on blood pressure in a rat hypertension model.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
11
2021
accepted:
11
04
2022
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
The benefits of lowering blood pressure (BP) are well established for the prevention of cardiovascular disease. While there are a number of pharmaceuticals available for lowering BP, there is considerable interest in using dietary modifications, lifestyle and behaviour changes as alternative strategies. Kukoamines, caffeic acid derivatives of polyamines present in solanaceous plants, have been reported to reduce BP. We investigated the effect of orally administered synthetic kukoamine A on BP in the Spontaneously Hypertensive Rat (SHR) laboratory animal model of hypertension. Prior to the hypertension study, we determined the safety of the synthetic kukoamine A in a single oral dose (5 or 10 mg kg-1 bodyweight) 14-day observational study in mice. No negative effects of the oral administration of kukoamine A were observed. We subsequently investigated the effect of daily oral doses of kukoamine A (0, 5, 10 mg kg-1 bodyweight) for 35 days using the SHR rat model of hypertension. The normotensive control Wistar Kyoto (WKY) strain was used to provide a baseline for normal BP in rats. We observed no effect of orally administered synthetic kukoamine A on arterial hypertension in this laboratory animal model of hypertension.
Identifiants
pubmed: 35522680
doi: 10.1371/journal.pone.0267567
pii: PONE-D-21-35268
pmc: PMC9075663
doi:
Substances chimiques
kukoamine A
0
Spermine
2FZ7Y3VOQX
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0267567Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Curr Hypertens Rep. 2016 Feb;18(2):17
pubmed: 26815004
Lancet. 2016 Mar 5;387(10022):957-967
pubmed: 26724178
J Sci Food Agric. 2016 Dec;96(15):4850-4860
pubmed: 27301296
Br J Pharmacol. 2012 Sep;167(2):298-312
pubmed: 22582712
Hypertension. 2015 Aug;66(2):254-9
pubmed: 26077565
J Agric Food Chem. 2012 Jan 11;60(1):95-9
pubmed: 22142260
Am J Physiol. 1992 Jun;262(6 Pt 1):E763-78
pubmed: 1616014
Bioorg Med Chem Lett. 1998 Jul 7;8(13):1751-6
pubmed: 9873428
Neurotox Res. 2017 Feb;31(2):259-268
pubmed: 27815817
Molecules. 2018 Apr 21;23(4):
pubmed: 29690528
Mol Med Rep. 2014 Nov;10(5):2483-8
pubmed: 25119059
J Agric Food Chem. 2012 Jul 11;60(27):6749-54
pubmed: 22224463
J Agric Food Chem. 2020 Jun 10;68(23):6248-6267
pubmed: 32422049
J Nutr Biochem. 2016 Nov;37:30-38
pubmed: 27596012
Cochrane Database Syst Rev. 2018 Apr 18;4:CD001841
pubmed: 29667175
Rapid Commun Mass Spectrom. 2008 Sep;22(18):2882-8
pubmed: 18720470
Int J Mol Sci. 2016 May 27;17(6):
pubmed: 27240356
Braz J Med Biol Res. 1997 Apr;30(4):521-32
pubmed: 9251774
JAMA Cardiol. 2017 Jul 1;2(7):775-781
pubmed: 28564682
Hypertension. 2016 Feb;67(2):288-93
pubmed: 26644239
BMC Public Health. 2018 Jun 11;18(1):722
pubmed: 29890937
Diabetes Metab Syndr Obes. 2020 May 26;13:1843-1853
pubmed: 32547146
Food Chem Toxicol. 1995 Mar;33(3):223-31
pubmed: 7896233
Am J Hypertens. 2008 Dec;21(12):1288-91
pubmed: 18846043
Phytomedicine. 2018 Jan 01;38:158-165
pubmed: 29425648
J Hypertens. 2006 Jun;24(6):1065-73
pubmed: 16685206
Nutrients. 2020 Oct 11;12(10):
pubmed: 33050676
Antioxidants (Basel). 2020 Apr 19;9(4):
pubmed: 32325920
J Med Food. 2006 Winter;9(4):587-90
pubmed: 17201650
Front Nutr. 2018 May 23;5:36
pubmed: 29876353
Food Chem. 2015 Apr 15;173:462-7
pubmed: 25466046
J Agric Food Chem. 2013 Oct 9;61(40):9534-50
pubmed: 24079774
Patient Prefer Adherence. 2016 Jul 27;10:1385-99
pubmed: 27528802
Cardiovasc Res. 1998 Jul;39(1):77-88
pubmed: 9764191
Methods Mol Biol. 2009;573:45-55
pubmed: 19763921
BMJ. 2016 May 17;353:i2351
pubmed: 27189229
Clin Exp Hypertens. 2006 Jul;28(5):439-49
pubmed: 16820341
J Vis Exp. 2009 May 15;(27):
pubmed: 19488026
J Anim Sci. 1998 Apr;76(4):1216-31
pubmed: 9581947
Planta Med. 2014 Nov;80(17):1580-7
pubmed: 25295669
Curr Hypertens Rep. 2014 Dec;16(12):499
pubmed: 25342643
Hypertension. 2013 Jun;61(6):1360-83
pubmed: 23608661
Front Pharmacol. 2019 Jan 22;9:1575
pubmed: 30723413
Patient Prefer Adherence. 2010 Nov 03;4:397-406
pubmed: 21206515
Evid Based Complement Alternat Med. 2019 Aug 14;2019:7198592
pubmed: 31485247
J Agric Food Chem. 2005 Jun 29;53(13):5461-6
pubmed: 15969534
JAMA Intern Med. 2018 Jan 1;178(1):28-36
pubmed: 29131895
Curr Hypertens Rep. 2013 Dec;15(6):694-702
pubmed: 24091874