Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study.

Adolescent Amino Acids Child Creatinine Diabetes Mellitus, Type 1 / diagnosis Diabetic Ketoacidosis / complications Diabetic Nephropathies / complications Female Histidine Humans Leucine Male Threonine Tryptophan
Aminoaciduria Diabetic ketoacidosis Diabetic nephropathy Pediatrics Type 1 diabetes

Journal

Journal of diabetes and its complications
ISSN: 1873-460X
Titre abrégé: J Diabetes Complications
Pays: United States
ID NLM: 9204583

Informations de publication

Date de publication:
06 2022
Historique:
received: 23 02 2022
revised: 17 04 2022
accepted: 17 04 2022
pubmed: 7 5 2022
medline: 24 5 2022
entrez: 6 5 2022
Statut: ppublish

Résumé

We examined changes in the excretion of various amino acids and in glycolysis and ketogenesis-related metabolites, during and after diabetic ketoacidosis (DKA) diagnosis, in youth with known or new onset type 1 diabetes (T1D). Urine samples were collected from 40 youth with DKA (52% boys, mean age 11 ± 4 years, venous pH 7.2 ± 0.1, blood glucose 451 ± 163 mg/dL) at 3 time points: 0-8 h and 12-24 h after starting an insulin infusion, and 3 months after hospital discharge. Mixed-effects models evaluated the changes in amino acids and other metabolites in the urine. Concentrations of urine histidine, threonine, tryptophan, and leucine per creatinine were highest at 0-8 h (148.8 ± 23.5, 59.5 ± 12.3, 15.4 ± 1.4, and 24.5 ± 2.4% of urine creatinine, respectively), and significantly decreased over 3 months (p = 0.028, p = 0.027, p = 0.019, and p < 0.0001, respectively). Urine histidine, threonine, tryptophan, and leucine per urine creatinine decreased by 10.6 ± 19.2, 0.7 ± 0.9, 1.3 ± 0.9, and 0.5 ± 0.3-fold, respectively, between 0 and 8 h and 3 months. In our study, DKA was associated with profound aminoaciduria, suggestive of proximal tubular dysfunction analogous to Fanconi syndrome.

Identifiants

DOI: 10.1016/j.jdiacomp.2022.108203 PMID: 35523653 PMC: PMC9119939
pubmed: 35523653
pii: S1056-8727(22)00105-2
doi: 10.1016/j.jdiacomp.2022.108203
pmc: PMC9119939
mid: NIHMS1803924
pii:
doi:

Substances chimiques

Amino Acids 0
Threonine 2ZD004190S
Histidine 4QD397987E
Tryptophan 8DUH1N11BX
Creatinine AYI8EX34EU
Leucine GMW67QNF9C

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108203

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL085757
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079310
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002535
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK116720
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK129720
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL145076
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL159292
Pays : United States
Organisme : NHLBI NIH HHS
ID : L40 HL159798
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK129211
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Références

Pflugers Arch. 2020 Sep;472(9):1345-1370
pubmed: 32144488
J Clin Endocrinol Metab. 2009 Oct;94(10):3687-95
pubmed: 19584191
Nutr Diabetes. 2017 Mar 13;7(3):e249
pubmed: 28287627
Pediatr Diabetes. 2019 Mar;20(2):172-179
pubmed: 30556249
Biochem Biophys Res Commun. 2015 Oct 16;466(2):240-6
pubmed: 26362188
Nat Med. 2013 Nov;19(11):1496-504
pubmed: 24141423
Cell Metab. 2009 Apr;9(4):311-26
pubmed: 19356713
Pediatr Diabetes. 2014 Sep;15 Suppl 20:154-79
pubmed: 25041509
Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1175-87
pubmed: 23512805
J Chromatogr. 1981 Sep 11;225(1):1-8
pubmed: 6795215
Diabetes Care. 2020 Jan;43(1):117-121
pubmed: 31601639
Iran J Kidney Dis. 2015 Mar;9(2):126-31
pubmed: 25851291
Curr Diab Rep. 2018 Mar 19;18(5):22
pubmed: 29557063
Pediatrics. 2014 Apr;133(4):e938-45
pubmed: 24685959
Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F667-F674
pubmed: 29357443
Pediatr Clin North Am. 2019 Feb;66(1):159-167
pubmed: 30454741
Diabetes Res Clin Pract. 2019 Sep;155:107797
pubmed: 31344382
Pediatr Diabetes. 2021 Nov;22(7):1031-1039
pubmed: 34435718
Diabetes. 2013 Feb;62(2):639-48
pubmed: 23043162
Pediatr Nephrol. 1993 Feb;7(1):23-6
pubmed: 8439475
Am J Epidemiol. 2017 Nov 1;186(9):1084-1096
pubmed: 29106475
Diabetes Technol Ther. 2012 Dec;14(12):1149-54
pubmed: 23009106
Oman Med J. 2010 Apr;25(2):114-7
pubmed: 22125712
JAMA. 2002 May 15;287(19):2511-8
pubmed: 12020331
Diabetes Res Clin Pract. 1991 May;12(2):91-7
pubmed: 1908767
Nephron Clin Pract. 2012;120(4):c179-84
pubmed: 22890468
Electrophoresis. 2013 Oct;34(19):2882-90
pubmed: 23857511
PLoS Med. 2005 Feb;2(2):e45
pubmed: 15737001
Endocr Res. 2002 Feb-May;28(1-2):91-102
pubmed: 12108794
Rass Fisiopatol Clin Ter. 1957 Nov;29(11):1203-21
pubmed: 13527674
J Clin Endocrinol Metab. 2010 Feb;95(2):513-21
pubmed: 19915016
Pediatr Obes. 2013 Feb;8(1):52-61
pubmed: 22961720
Clin J Am Soc Nephrol. 2014 Sep 5;9(9):1627-38
pubmed: 23908456
Diabetes Metab Syndr. 2020 Jul - Aug;14(4):303-310
pubmed: 32298981
Pediatr Diabetes. 2021 Feb;22(1):40-46
pubmed: 31943641
J Am Soc Nephrol. 2017 Apr;28(4):1023-1039
pubmed: 28143897

Auteurs

Isabella Melena (I)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA.

Federica Piani (F)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO, USA; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Kalie L Tommerdahl (KL)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA; Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.

Cameron Severn (C)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Biostatistics and Informatics, Colorado School of Public Health, CO, USA.

Linh T Chung (LT)

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO, USA.

Alexis MacDonald (A)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA.

Carissa Vinovskis (C)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA.

David Cherney (D)

Department of Medicine, Division of Nephrology, University of Toronto School of Medicine, Toronto, Ontario, Canada.

Laura Pyle (L)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Biostatistics and Informatics, Colorado School of Public Health, CO, USA.

Carlos A Roncal-Jimenez (CA)

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO, USA.

Miguel A Lanaspa (MA)

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO, USA.

Arleta Rewers (A)

Department of Pediatrics, Section of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.

Daniël H van Raalte (DH)

Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUmc, Amsterdam, the Netherlands.

Gabriel Cara-Fuentes (G)

Department of Pediatrics, Section of Nephrology, University of Colorado School of Medicine, Aurora, CO, USA.

Chirag R Parikh (CR)

Department of Medicine, Division of Nephrology, Johns Hopkins University, Baltimore, MD, USA.

Robert G Nelson (RG)

Chronic Kidney Disease Section, Phoenix Epidemiology and Clinical Research Branch, NIDDK, Phoenix, AZ, USA.

Meda E Pavkov (ME)

Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Kristen J Nadeau (KJ)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA.

Richard J Johnson (RJ)

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO, USA.

Petter Bjornstad (P)

Department of Pediatrics, Section of Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: petter.m.bjornstad@cuanschutz.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Créatinine › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Acidocétose diabétique › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Néphropathies diabétiques › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Histidine › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Leucine › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Thréonine › Aminoaciduria and metabolic dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Aminoaciduria and metabolic dysregulation...