Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 05 2022
06 05 2022
Historique:
received:
17
11
2021
accepted:
21
04
2022
entrez:
6
5
2022
pubmed:
7
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.
Identifiants
pubmed: 35523782
doi: 10.1038/s41467-022-30219-5
pii: 10.1038/s41467-022-30219-5
pmc: PMC9076825
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2494Subventions
Organisme : Medical Research Council
ID : MR/J01477X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P028071/1
Pays : United Kingdom
Organisme : Department of Health
ID : 17.63.91
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107755/Z/15/Z
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
Références
CMAJ. 2021 Oct 25;193(42):E1619-E1625
pubmed: 34610919
Bioinformatics. 2018 Dec 1;34(23):4121-4123
pubmed: 29790939
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
Exp Biol Med (Maywood). 2021 Apr;246(8):960-970
pubmed: 33325750
Nat Commun. 2021 Dec 13;12(1):7251
pubmed: 34903718
Environ Res. 2022 Apr 15;206:112240
pubmed: 34688639
Nat Biotechnol. 2020 Mar;38(3):276-278
pubmed: 32055031
Nat Rev Genet. 2021 Dec;22(12):757-773
pubmed: 34535792
PLoS One. 2021 Apr 21;16(4):e0249271
pubmed: 33882054
Nat Med. 2021 Jul;27(7):1131-1133
pubmed: 34045737
BMC Bioinformatics. 2020 May 24;21(1):211
pubmed: 32448124
N Engl J Med. 2021 Oct 7;385(15):1401-1406
pubmed: 34407341
Science. 2021 Oct 22;374(6566):423-431
pubmed: 34672751
N Engl J Med. 2021 Aug 12;385(7):585-594
pubmed: 34289274
Genome Biol. 2019 Jun 24;20(1):129
pubmed: 31234903
J Transl Med. 2020 Apr 22;18(1):179
pubmed: 32321524
Nat Med. 2021 Dec;27(12):2136-2143
pubmed: 34728831
Science. 2021 Nov 19;374(6570):995-999
pubmed: 34648303
Nat Microbiol. 2020 Nov;5(11):1403-1407
pubmed: 32669681