3'untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance.

3' Untranslated Regions / genetics Binding Sites / genetics Child Genes, Tumor Suppressor Humans Neoplasms / genetics Promoter Regions, Genetic

Journal

Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562

Informations de publication

Date de publication:
06 2022
Historique:
received: 03 12 2021
accepted: 28 04 2022
revised: 26 04 2022
pubmed: 7 5 2022
medline: 9 6 2022
entrez: 6 5 2022
Statut: ppublish

Résumé

Cancer-related genes have evolved specific genetic and genomic features to favor tumor suppression. Previously we reported that tumor suppressor genes (TSGs) acquired high promoter CpG dinucleotide frequencies during evolution to maintain high expression in normal tissues and resist cancer-specific downregulation. In this study, we investigated whether 3'untranslated regions (3'UTRs) of TSGs have evolved specific features to carry out similar functions. We found that 3'UTRs of TSGs, especially those involved in multiple histological types and pediatric cancers, are longer than those of non-cancer genes. 3'UTRs of TSGs also exhibit higher density of binding sites for RNA-binding proteins (RBPs), particularly those having high affinities to C-rich motifs. Both longer 3'UTR length and RBP binding sites enrichment are correlated with higher gene expression in normal tissues across tissue types. Moreover, both features together with the correlated N

Identifiants

DOI: 10.1038/s41388-022-02343-5 PMID: 35523946
pubmed: 35523946
doi: 10.1038/s41388-022-02343-5
pii: 10.1038/s41388-022-02343-5
doi:

Substances chimiques

3' Untranslated Regions 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3278-3288

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Dan Huang (D)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.
ORCID: 0000-0003-3022-5772

Xiansong Wang (X)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.

Ziheng Huang (Z)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.

Yingzhi Liu (Y)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.

Xiaodong Liu (X)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.

Tony Gin (T)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
ORCID: 0000-0001-7283-6761

Sunny Hei Wong (SH)

CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
ORCID: 0000-0002-3354-9310

Jun Yu (J)

CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
ORCID: 0000-0001-5008-2153

Lin Zhang (L)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.

Matthew Tak Vai Chan (MTV)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. mtvchan@cuhk.edu.hk.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China. mtvchan@cuhk.edu.hk.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. mtvchan@cuhk.edu.hk.
ORCID: 0000-0002-3574-7855

Huarong Chen (H)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. hchen2@cuhk.edu.hk.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China. hchen2@cuhk.edu.hk.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. hchen2@cuhk.edu.hk.
State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. hchen2@cuhk.edu.hk.
ORCID: 0000-0003-2192-1864

William Ka Kei Wu (WKK)

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. wukakei@cuhk.edu.hk.
CUHK Shenzhen Research Institute, Shenzhen, Guangdong, People's Republic of China. wukakei@cuhk.edu.hk.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. wukakei@cuhk.edu.hk.
State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. wukakei@cuhk.edu.hk.
ORCID: 0000-0002-5662-5240

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 3' non traduites › 3'untranslated regions of tumor suppressor...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › 3'untranslated regions of tumor suppressor...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › 3'untranslated regions of tumor suppressor...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes suppresseurs de tumeur › 3'untranslated regions of tumor suppressor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 3'untranslated regions of tumor suppressor...
questionsmedicales.fr › Tumeurs › 3'untranslated regions of tumor suppressor...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › 3'untranslated regions of tumor suppressor...