Prevalence of incidental intracranial findings on magnetic resonance imaging: a systematic review and meta-analysis.

Brain Neoplasms / diagnostic imaging Child Humans Incidental Findings Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Prevalence
Aneurysm Incidental finding Incidentaloma MRI Magnetic resonance imaging

Journal

Acta neurochirurgica
ISSN: 0942-0940
Titre abrégé: Acta Neurochir (Wien)
Pays: Austria
ID NLM: 0151000

Informations de publication

Date de publication:
10 2022
Historique:
received: 22 02 2022
accepted: 22 04 2022
pubmed: 8 5 2022
medline: 1 10 2022
entrez: 7 5 2022
Statut: ppublish

Résumé

As the volume and fidelity of magnetic resonance imaging (MRI) of the brain increase, observation of incidental findings may also increase. We performed a systematic review and meta-analysis to determine the prevalence of various incidental findings. PubMed/MEDLINE, EMBASE and SCOPUS were searched from inception to May 24, 2021. We identified 6536 citations and included 35 reports of 34 studies, comprising 40,777 participants. A meta-analysis of proportions was performed, and age-stratified estimates for each finding were derived from age-adjusted non-linear models. Vascular abnormalities were observed in 423/35,706 participants (9.1/1000 scans, 95%CI 5.2-14.2), ranging from 2/1000 scans (95%CI 0-7) in 1-year-olds to 16/1000 scans (95%CI 1-43) in 80-year-olds. Of these, 204/34,306 were aneurysms (3.1/1000 scans, 95%CI 1-6.3), which ranged from 0/1000 scans (95%CI 0-5) at 1 year of age to 6/1000 scans (95%CI 3-9) at 60 years. Neoplastic abnormalities were observed in 456/39,040 participants (11.9/1000 scans, 95%CI 7.5-17.2), ranging from 0.2/1000 scans (95%CI 0-10) in 1-year-olds to 34/1000 scans (95%CI 12-66) in 80-year-olds. Meningiomas were the most common, in 246/38,076 participants (5.3/1000 scans, 95%CI 2.3-9.5), ranging from 0/1000 scans (95%CI 0-2) in 1-year-olds to 17/1000 scans (95%CI 4-37) in 80-year-olds. Chiari malformations were observed in 109/27,408 participants (3.7/1000 scans, 95%CI 1.8-6.3), pineal cysts in 1176/32,170 (9/1000 scans, 95%CI 1.8-21.4) and arachnoid cysts in 414/36,367 (8.5/1000 scans, 95%CI 5.8-11.8). Incidental findings are common on brain MRI and may result in substantial resource expenditure and patient anxiety but are often of little clinical significance.

Sections du résumé

BACKGROUND
As the volume and fidelity of magnetic resonance imaging (MRI) of the brain increase, observation of incidental findings may also increase. We performed a systematic review and meta-analysis to determine the prevalence of various incidental findings.
METHODS
PubMed/MEDLINE, EMBASE and SCOPUS were searched from inception to May 24, 2021. We identified 6536 citations and included 35 reports of 34 studies, comprising 40,777 participants. A meta-analysis of proportions was performed, and age-stratified estimates for each finding were derived from age-adjusted non-linear models.
RESULTS
Vascular abnormalities were observed in 423/35,706 participants (9.1/1000 scans, 95%CI 5.2-14.2), ranging from 2/1000 scans (95%CI 0-7) in 1-year-olds to 16/1000 scans (95%CI 1-43) in 80-year-olds. Of these, 204/34,306 were aneurysms (3.1/1000 scans, 95%CI 1-6.3), which ranged from 0/1000 scans (95%CI 0-5) at 1 year of age to 6/1000 scans (95%CI 3-9) at 60 years. Neoplastic abnormalities were observed in 456/39,040 participants (11.9/1000 scans, 95%CI 7.5-17.2), ranging from 0.2/1000 scans (95%CI 0-10) in 1-year-olds to 34/1000 scans (95%CI 12-66) in 80-year-olds. Meningiomas were the most common, in 246/38,076 participants (5.3/1000 scans, 95%CI 2.3-9.5), ranging from 0/1000 scans (95%CI 0-2) in 1-year-olds to 17/1000 scans (95%CI 4-37) in 80-year-olds. Chiari malformations were observed in 109/27,408 participants (3.7/1000 scans, 95%CI 1.8-6.3), pineal cysts in 1176/32,170 (9/1000 scans, 95%CI 1.8-21.4) and arachnoid cysts in 414/36,367 (8.5/1000 scans, 95%CI 5.8-11.8).
CONCLUSION
Incidental findings are common on brain MRI and may result in substantial resource expenditure and patient anxiety but are often of little clinical significance.

Identifiants

DOI: 10.1007/s00701-022-05225-7 PMID: 35525892 PMC: PMC9519720
pubmed: 35525892
doi: 10.1007/s00701-022-05225-7
pii: 10.1007/s00701-022-05225-7
pmc: PMC9519720
doi:

Types de publication

Journal Article Meta-Analysis Review Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2751-2765

Informations de copyright

© 2022. The Author(s).

Références

Neuro Oncol. 2021 Nov 2;23(11):1821-1834
pubmed: 34181733
Radiol Clin North Am. 2011 Mar;49(2):245-55
pubmed: 21333776
J Am Acad Child Adolesc Psychiatry. 2006 Aug;45(8):1000-1006
pubmed: 16865043
JAMA. 1999 Jul 7;282(1):36-9
pubmed: 10404909
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Stroke. 1999 Aug;30(8):1621-7
pubmed: 10436111
Health Sci Rep. 2020 Jul 27;3(3):e178
pubmed: 32728636
Clin Neurol Neurosurg. 2020 Sep;196:106019
pubmed: 32585532
Brain Imaging Behav. 2017 Oct;11(5):1302-1315
pubmed: 27722828
Ann Intern Med. 1994 May 15;120(10):817-20
pubmed: 8154641
J Comput Assist Tomogr. 2010 Jul;34(4):596-600
pubmed: 20657230
N Engl J Med. 2017 Oct 19;377(16):1593-1595
pubmed: 29045203
Int J Stroke. 2022 Jan;17(1):30-36
pubmed: 34042530
Brain Imaging Behav. 2015 Mar;9(1):32-42
pubmed: 25403715
JAMA Netw Open. 2019 Oct 2;2(10):e1913325
pubmed: 31617925
Herz. 2007 Aug;32(5):387-94
pubmed: 17687528
Acta Neurochir (Wien). 2014 Feb;156(2):375-81
pubmed: 24272523
Lancet Neurol. 2011 Jul;10(7):626-36
pubmed: 21641282
BMJ Open. 2017 Mar 24;7(3):e013215
pubmed: 28341686
J Clin Epidemiol. 2012 Sep;65(9):934-9
pubmed: 22742910
J Clin Endocrinol Metab. 2011 Apr;96(4):905-12
pubmed: 21474687
J Clin Epidemiol. 2014 Aug;67(8):897-903
pubmed: 24794697
PLoS One. 2014 Sep 26;9(9):e107840
pubmed: 25259581
Lancet. 2003 Jul 12;362(9378):103-10
pubmed: 12867109
Childs Nerv Syst. 2018 Jul;34(7):1345-1352
pubmed: 29556697
J Clin Endocrinol Metab. 2011 Apr;96(4):35A-6A
pubmed: 21474684
JAMA Neurol. 2019 May 1;76(5):588-597
pubmed: 30659573
JAMA Neurol. 2021 May 1;78(5):578-587
pubmed: 33749724
Lakartidningen. 1989 Nov 15;86(46):3991-4
pubmed: 2586213
Acta Psychiatr Scand. 2002 Nov;106(5):331-6
pubmed: 12366466
Int J Nanomedicine. 2019 Oct 21;14:8321-8344
pubmed: 31695370
BMJ. 2009 Aug 17;339:b3016
pubmed: 19687093
J Neurol Sci. 2006 Jan 15;240(1-2):81-4
pubmed: 16256141
Dement Geriatr Cogn Disord. 2019;48(3-4):123-130
pubmed: 31805574
Br J Radiol. 2010 Jun;83(990):456-65
pubmed: 20335427
Lancet. 2002 Oct 26;360(9342):1267-74
pubmed: 12414200
Neurol Med Chir (Tokyo). 2001 Sep;41(9):431-4; discussion 435
pubmed: 11593969
J Am Coll Radiol. 2016 Dec;13(12 Pt B):1608-1614
pubmed: 27888949
Acad Radiol. 2016 Sep;23(9):1162-9
pubmed: 27287715
Radiology. 2016 Nov;281(2):507-515
pubmed: 27337027
Radiology. 1997 Jan;202(1):41-6
pubmed: 8988190
AJNR Am J Neuroradiol. 2019 Nov;40(11):1818-1823
pubmed: 31624116
AJR Am J Roentgenol. 2006 Oct;187(4):1043-7
pubmed: 16985155
J Epidemiol. 2010;20 Suppl 2:S498-504
pubmed: 20179362
BMC Neurol. 2005 Oct 05;5:18
pubmed: 16207376
Neurology. 2017 Apr 25;88(17):1600-1606
pubmed: 28363976
Neurology. 2004 Mar 23;62(6):888-90
pubmed: 15037687
Front Neurosci. 2021 Feb 19;15:631087
pubmed: 33679312
Neurology. 2013 Oct 15;81(16):1387-91
pubmed: 24042095
Acta Neuropsychiatr. 2008 Apr;20(2):87-90
pubmed: 25385468
World Neurosurg. 2020 Jun;138:e725-e735
pubmed: 32200011
Eur J Paediatr Neurol. 2014 Mar;18(2):163-70
pubmed: 24268890
BMJ. 2018 Jun 18;361:k2387
pubmed: 29914908
Neurol Clin Pract. 2017 Jun;7(3):274-277
pubmed: 30107008
Syst Rev. 2016 Dec 5;5(1):210
pubmed: 27919275
Neuro Oncol. 2020 Feb 20;22(2):278-289
pubmed: 31603516
AJNR Am J Neuroradiol. 2002 Nov-Dec;23(10):1674-7
pubmed: 12427622
Brain Imaging Behav. 2017 Feb;11(1):293-299
pubmed: 26843003
Neuro Oncol. 2002 Oct;4(4):278-99
pubmed: 12356358
J Neuroradiol. 2020 Sep;47(5):343-348
pubmed: 30098369
Brain Imaging Behav. 2018 Jun;12(3):860-869
pubmed: 28676986
N Engl J Med. 2007 Nov 1;357(18):1821-8
pubmed: 17978290
Am Fam Physician. 2014 Dec 1;90(11):784-9
pubmed: 25611713
J Med Ethics. 2009 Mar;35(3):194-9
pubmed: 19251973
Stroke. 2017 Aug;48(8):2105-2112
pubmed: 28667020
Trop Med Int Health. 2013 Apr;18(4):398-402
pubmed: 23331928
PLoS One. 2013 Aug 15;8(8):e71467
pubmed: 23967214
Brain Cogn. 2002 Dec;50(3):358-65
pubmed: 12480483
PLoS One. 2016 Mar 07;11(3):e0151080
pubmed: 26950220
Neurosurg Focus. 2019 Jul 1;47(1):E16
pubmed: 31261120
BMJ Open. 2019 Jul 31;9(7):e029502
pubmed: 31371298
AJNR Am J Neuroradiol. 2012 Nov;33(10):1971-4
pubmed: 22723061
Int J Geriatr Psychiatry. 2009 Feb;24(2):109-17
pubmed: 18637641
Res Synth Methods. 2019 Dec;10(4):606-614
pubmed: 31355546
Sci Rep. 2020 Jun 11;10(1):9474
pubmed: 32528044
Sci Rep. 2019 Jan 24;9(1):464
pubmed: 30679548
J Am Coll Radiol. 2010 Dec;7(12):949-55
pubmed: 21129686
N Engl J Med. 2008 Feb 21;358(8):853; author reply 854-5
pubmed: 18287610
AJNR Am J Neuroradiol. 2013 Oct;34(10):2021-5
pubmed: 23811972

Auteurs

Divya Elizabeth Sunny (DE)

National Neurosurgical Centre, Beaumont Hospital, Dublin 9, Ireland.
School of Medicine, University College Dublin, Dublin, Ireland.

Michael Amoo (M)

National Neurosurgical Centre, Beaumont Hospital, Dublin 9, Ireland. michaelamoo@rcsi.ie.
University of Medical and Health Sciences, Royal College of Surgeons Ireland, Dublin, Ireland. michaelamoo@rcsi.ie.
ORCID: 0000-0001-6886-6714

Maryam Al Breiki (M)

National Neurosurgical Centre, Beaumont Hospital, Dublin 9, Ireland.
School of Medicine, University College Dublin, Dublin, Ireland.

Elite Dong Wen Teng (EDW)

National Neurosurgical Centre, Beaumont Hospital, Dublin 9, Ireland.
School of Medicine, University College Dublin, Dublin, Ireland.

Jack Henry (J)

National Neurosurgical Centre, Beaumont Hospital, Dublin 9, Ireland.
School of Medicine, University College Dublin, Dublin, Ireland.
ORCID: 0000-0001-5662-198X

Mohsen Javadpour (M)

National Neurosurgical Centre, Beaumont Hospital, Dublin 9, Ireland. mjavadpour@rcsi.ie.
University of Medical and Health Sciences, Royal College of Surgeons Ireland, Dublin, Ireland. mjavadpour@rcsi.ie.
Department of Academic Neurology, Trinity College Dublin, Dublin, Ireland. mjavadpour@rcsi.ie.
ORCID: 0000-0001-9836-1741

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Prevalence of incidental intracranial findings...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Prevalence of incidental intracranial findings...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prevalence of incidental intracranial findings...
questionsmedicales.fr › Diagnostic › Résultats fortuits › Prevalence of incidental intracranial findings...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Prevalence of incidental intracranial findings...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Prevalence of incidental intracranial findings...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Prevalence of incidental intracranial findings...