Chromosomal instability as a source of genomic plasticity.
Cancer Evolution
Chromosomal Instability
Micronuclei
ecDNA
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
10
01
2022
revised:
27
02
2022
accepted:
31
03
2022
pubmed:
9
5
2022
medline:
3
6
2022
entrez:
8
5
2022
Statut:
ppublish
Résumé
Chromosomal instability (CIN) is a hallmark of the most aggressive malignancies. Features of these tumors include complex genomic rearrangements, the presence of mis-segregated chromosomes in micronuclei, and extrachromosomal DNA (ecDNA) formation. Here, we review the development of CIN, and examine CIN in the context of cancer evolution, tumor genomic evolution, and therapeutic resistance. We also discuss the role of whole-genome duplications, breakage-fusion-bridge cycles, ecDNA or double minutes in gene amplification promoting tumor evolution.
Identifiants
pubmed: 35526333
pii: S0959-437X(22)00022-3
doi: 10.1016/j.gde.2022.101913
pmc: PMC9156567
mid: NIHMS1796029
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101913Subventions
Organisme : NCI NIH HHS
ID : T32 CA009207
Pays : United States
Organisme : NIH HHS
ID : DP5 OD026395
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NHLBI NIH HHS
ID : K30 HL004160
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA247749
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA256188
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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