Peroxynitrous acid-modified extracellular matrix alters gene and protein expression in human coronary artery smooth muscle cells and induces a pro-inflammatory phenotype.
3-Nitrotyrosine
Extracellular matrix
Peroxynitrite
Protein oxidation
Smooth muscle cell
Versican
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
17
11
2021
revised:
29
03
2022
accepted:
03
05
2022
pubmed:
9
5
2022
medline:
3
6
2022
entrez:
8
5
2022
Statut:
ppublish
Résumé
Leukocytes produce oxidants at inflammatory sites, including within the artery wall during the development of atherosclerosis. Developing lesions contain high numbers of activated leukocytes that generate reactive nitrogen species, including peroxynitrite/peroxynitrous acid (ONOO
Identifiants
pubmed: 35526806
pii: S0891-5849(22)00176-9
doi: 10.1016/j.freeradbiomed.2022.05.001
pii:
doi:
Substances chimiques
Oxidants
0
Vascular Cell Adhesion Molecule-1
0
Peroxynitrous Acid
14691-52-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-52Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.