Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy.
AE2
HVCN1
Lymphocytes
adoptive cell therapy
intracellular pH
tumor microenvironment
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
The high metabolic activity and insufficient perfusion of tumors leads to the acidification of the tumor microenvironment (TME) that may inhibit the antitumor T cell activity. We found that pharmacological inhibition of the acid loader chloride/bicarbonate anion exchanger 2 (Ae2), with 4,4'-diisothiocyanatostilbene-2,2'-disulfonicacid (DIDS) enhancedCD4
Identifiants
pubmed: 35529677
doi: 10.1080/2162402X.2022.2070337
pii: 2070337
pmc: PMC9067511
doi:
Substances chimiques
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Q1O6DSW23R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2070337Informations de copyright
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the author(s).
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