The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae.
eicosanoids
ferroptosis
lipid peroxidation
oxidative stress
recombinant proteins
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
02
2022
accepted:
01
04
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
epublish
Résumé
Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of mammals. The reaction specificity of these enzymes is decisive for their biological functions and ALOX classification is based on this enzyme property. Comparing the amino acid sequences and the functional properties of selected mammalian ALOX15 orthologs we previously hypothesized that the reaction specificity of these enzymes can be predicted based on their amino acid sequences (Triad Concept) and that mammals, which are ranked in evolution below gibbons, express arachidonic acid 12-lipoxygenating ALOX15 orthologs. In contrast, Hominidae involving the great apes and humans possess 15-lipoxygenating enzymes (Evolutionary Hypothesis). These two hypotheses were based on sequence data of some 60 mammalian ALOX15 orthologs and about half of them were functionally characterized. Here, we compared the ALOX15 sequences of 152 mammals representing all major mammalian subclades expressed 44 novel ALOX15 orthologs and performed extensive mutagenesis studies of their triad determinants. We found that
Identifiants
pubmed: 35531094
doi: 10.3389/fcell.2022.871585
pii: 871585
pmc: PMC9068934
doi:
Types de publication
Journal Article
Langues
eng
Pagination
871585Informations de copyright
Copyright © 2022 Heydeck, Reisch, Schäfer, Kakularam, Roigas, Stehling, Püschel and Kuhn.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Clin Invest. 1997 Mar 1;99(5):888-93
pubmed: 9062346
Chem Rev. 2011 Oct 12;111(10):5922-43
pubmed: 21766791
Science. 2013 Feb 8;339(6120):662-7
pubmed: 23393258
Arch Biochem Biophys. 2015 Apr 1;571:50-7
pubmed: 25731857
Biochim Biophys Acta. 2016 Jan;1861(1):1-11
pubmed: 26456699
FEBS J. 2021 Feb;288(4):1387-1406
pubmed: 32627384
J Biol Chem. 1990 Mar 25;265(9):5113-20
pubmed: 2318885
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3400-4
pubmed: 4215079
Nature. 1991 Nov 14;354(6349):149-52
pubmed: 1944593
ScientificWorldJournal. 2010 Jun 02;10:1048-64
pubmed: 20526535
J Biol Chem. 2010 Feb 19;285(8):5369-76
pubmed: 20026599
Am J Physiol. 1992 Jul;263(1):1 p preceding L1
pubmed: 1636733
Biochim Biophys Acta. 1986 Dec 22;864(3-4):471-95
pubmed: 3098292
J Biol Chem. 2001 Jan 5;276(1):773-9
pubmed: 11027682
Nature. 2002 Mar 14;416(6877):165-8
pubmed: 11894091
Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4266-75
pubmed: 27412860
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6148-52
pubmed: 9177185
Redox Biol. 2015 Dec;6:297-310
pubmed: 26298204
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158550
pubmed: 31676437
Biochim Biophys Acta. 2014 Oct;1842(10):1460-6
pubmed: 25025884
J Biol Chem. 2010 Dec 17;285(51):39866-75
pubmed: 20921226
Periodontol 2000. 2013 Oct;63(1):149-64
pubmed: 23931059
Biochem Biophys Res Commun. 1993 May 14;192(3):1023-9
pubmed: 8507177
J Mol Biol. 1998 May 22;278(5):935-48
pubmed: 9600854
FEBS Lett. 1975 Dec 1;60(1):149-52
pubmed: 6318
J Lipid Res. 2013 May;54(5):1397-409
pubmed: 23475662
Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:303-12
pubmed: 12432925
Science. 2003 Jan 17;299(5605):400-2
pubmed: 12532019
J Clin Invest. 1999 Jun;103(11):1597-604
pubmed: 10359569
J Biol Chem. 1998 Sep 4;273(36):23225-32
pubmed: 9722553
Chem Rev. 2011 Oct 12;111(10):5866-98
pubmed: 21936577
Arch Biochem Biophys. 2010 Nov 15;503(2):161-74
pubmed: 20801095
J Biol Chem. 1990 Oct 25;265(30):18351-61
pubmed: 2120232
J Biol Chem. 1982 Jun 10;257(11):6050-5
pubmed: 6804460
Gene. 2015 Nov 15;573(1):1-32
pubmed: 26216303
J Biol Chem. 1994 May 13;269(19):13979-87
pubmed: 8188678
Genome Res. 2008 Jun;18(6):965-73
pubmed: 18463302
Prostaglandins Leukot Essent Fatty Acids. 2010 Feb-Mar;82(2-3):121-9
pubmed: 20106647
Nature. 1998 Sep 24;395(6700):392-5
pubmed: 9759730
Biochim Biophys Acta. 1993 Jul 21;1169(1):80-9
pubmed: 8334154
PLoS One. 2013;8(4):e60019
pubmed: 23560065
PLoS Biol. 2010 Jul 27;8(7):e1000436
pubmed: 20668664
J Lipid Res. 1994 Oct;35(10):1749-59
pubmed: 7852852
Nature. 2014 Apr 24;508(7497):488-93
pubmed: 24759410
J Biol Chem. 1999 Dec 24;274(52):37345-50
pubmed: 10601303
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9967-72
pubmed: 9707584
Science. 2013 Aug 9;341(6146):613
pubmed: 23929967
Prog Lipid Res. 2018 Oct;72:55-74
pubmed: 30237084
Nature. 2008 May 8;453(7192):175-83
pubmed: 18464734
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb;1863(2):152-164
pubmed: 29146531
Biochim Biophys Acta. 1995 Jan 3;1254(1):112-6
pubmed: 7811740
Curr Opin Pharmacol. 2010 Apr;10(2):166-72
pubmed: 20226737
J Biol Chem. 1986 Dec 15;261(35):16714-21
pubmed: 3782139
Biochim Biophys Acta. 1994 Jan 20;1210(3):308-16
pubmed: 8305485
Biochim Biophys Acta. 2015 Apr;1851(4):331-9
pubmed: 25152163
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):372-385
pubmed: 30599203
Proc Biol Sci. 2007 May 7;274(1614):1159-66
pubmed: 17329227
Genome Res. 2004 Dec;14(12):2412-23
pubmed: 15574820
Eur J Biochem. 1993 Mar 1;212(2):605-12
pubmed: 8444196
BMC Evol Biol. 2007 Nov 13;7:224
pubmed: 17999766
Biochim Biophys Acta. 2015 Apr;1851(4):308-30
pubmed: 25316652
Arch Biochem Biophys. 2015 Jan 1;565:17-24
pubmed: 25447821
Protein Eng. 1995 Mar;8(3):275-82
pubmed: 7479689
J Mol Biol. 1996 Dec 20;264(5):1145-53
pubmed: 9000636
Science. 2013 Aug 9;341(6146):613
pubmed: 23929968
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6744-9
pubmed: 9618483
Biol Rev Camb Philos Soc. 2000 May;75(2):253-95
pubmed: 10881389