Use of Bulk Segregant Analysis for Determining the Genetic Basis of Azole Resistance in the Opportunistic Pathogen

Antifungal Agents / pharmacology Aspergillus fumigatus / metabolism Azoles / pharmacology Drug Resistance, Fungal / genetics Fungal Proteins / genetics Itraconazole / metabolism Microbial Sensitivity Tests
CYP51 antifungal filamentous fungi genomics itraconazole next-generation sequencing

Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2022
Historique:
received: 22 12 2021
accepted: 03 03 2022
entrez: 9 5 2022
pubmed: 10 5 2022
medline: 11 5 2022
Statut: epublish

Résumé

A sexual cycle was described in 2009 for the opportunistic fungal pathogen

Identifiants

DOI: 10.3389/fcimb.2022.841138 PMID: 35531335 PMC: PMC9069965
pubmed: 35531335
doi: 10.3389/fcimb.2022.841138
pmc: PMC9069965
doi:

Substances chimiques

Antifungal Agents 0
Azoles 0
Fungal Proteins 0
Itraconazole 304NUG5GF4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

841138

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2022 Ashton, Sang, Blythe, Zadik, Holmes, Malla, Camps, Wright, Melchers, Verweij and Dyer.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

George D Ashton (GD)

School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.

Fei Sang (F)

DeepSeq, Centre for Genetics and Genomics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

Martin Blythe (M)

DeepSeq, Centre for Genetics and Genomics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

Daniel Zadik (D)

DeepSeq, Centre for Genetics and Genomics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

Nadine Holmes (N)

DeepSeq, Centre for Genetics and Genomics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

Sunir Malla (S)

DeepSeq, Centre for Genetics and Genomics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

Simone M T Camps (SMT)

Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.

Victoria Wright (V)

DeepSeq, Centre for Genetics and Genomics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

Willem J G Melchers (WJG)

Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.

Paul E Verweij (PE)

Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.

Paul S Dyer (PS)

School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Use of Bulk Segregant Analysis for Determining...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Aspergillus fumigatus › Use of Bulk Segregant Analysis for Determining...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Use of Bulk Segregant Analysis for Determining...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance des champignons aux médicaments › Use of Bulk Segregant Analysis for Determining...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Use of Bulk Segregant Analysis for Determining...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Itraconazole › Use of Bulk Segregant Analysis for Determining...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Use of Bulk Segregant Analysis for Determining...