Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury.
Warburg effect
cardiopulmonary bypass
congenital heart disease
kynurenic acid
metabolism
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 07 2022
01 07 2022
Historique:
pubmed:
10
5
2022
medline:
24
6
2022
entrez:
9
5
2022
Statut:
ppublish
Résumé
Acute kidney injury (AKI) is a common cause of morbidity after congenital heart disease surgery. Progress on diagnosis and therapy remains limited, however, in part due to poor mechanistic understanding and a lack of relevant translational models. Metabolomic approaches could help identify novel mechanisms of injury and potential therapeutic targets. In the present study, we used a piglet model of cardiopulmonary bypass with deep hypothermic circulatory arrest (CPB/DHCA) and targeted metabolic profiling of kidney tissue, urine, and serum to evaluate metabolic changes specific to animals with histological acute kidney injury. CPB/DHCA animals with acute kidney injury were compared with those without acute kidney injury and mechanically ventilated controls. Acute kidney injury occurred in 10 of 20 CPB/DHCA animals 4 h after CPB/DHCA and 0 of 7 control animals. Injured kidneys showed a distinct tissue metabolic profile compared with uninjured kidneys (
Identifiants
pubmed: 35532069
doi: 10.1152/ajprenal.00039.2022
pmc: PMC9236877
doi:
Substances chimiques
Purines
0
Tryptophan
8DUH1N11BX
Banques de données
figshare
['10.6084/m9.figshare.19666416.v1', '10.6084/m9.figshare.19181945.v1']
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F20-F32Subventions
Organisme : American Heart Association-American Stroke Association
ID : 17IRG33410724
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL123634
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL156936
Pays : United States
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