Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of


Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
10 05 2022
Historique:
received: 18 07 2021
accepted: 19 04 2022
pubmed: 11 5 2022
medline: 14 5 2022
entrez: 10 5 2022
Statut: epublish

Résumé

Pitt-Hopkins syndrome (PTHS) is a neurodevelopmental disorder caused by monoallelic mutation or deletion in the

Identifiants

pubmed: 35535852
doi: 10.7554/eLife.72290
pii: 72290
pmc: PMC9090324
doi:
pii:

Substances chimiques

Tcf4 protein, mouse 0
Transcription Factor 4 0

Banques de données

GEO
['GSE123335', 'GSE60361']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD103573
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114086
Pays : United States

Informations de copyright

© 2022, Kim et al.

Déclaration de conflit d'intérêts

HK, EG, AD, NB, HV, XZ, AH, KR, JS, AK, BP No competing interests declared

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Auteurs

Hyojin Kim (H)

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Eric B Gao (EB)

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Adam Draper (A)

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Noah C Berens (NC)

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Hanna Vihma (H)

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Xinyuan Zhang (X)

Department of Chemistry and Biochemistry, Bates College, Lewiston, United States.

Alexandra Higashi-Howard (A)

Department of Chemistry and Biochemistry, Bates College, Lewiston, United States.

Kimberly D Ritola (KD)

HHMI Janelia Research Campus, Ashburn, United States.

Jeremy M Simon (JM)

Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hil, Chapel Hill, United States.

Andrew J Kennedy (AJ)

Department of Chemistry and Biochemistry, Bates College, Lewiston, United States.

Benjamin D Philpot (BD)

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hil, Chapel Hill, United States.

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Classifications MeSH