Intracellular mono-ADP-ribosyltransferases at the host-virus interphase.
ADP-ribosylation
Alphavirus
Chikungunya virus
Coronavirus
Hydrolase
Interferon
MARylation
Macrodomain
PARP
Pattern recognition receptors
Signaling
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
10 May 2022
10 May 2022
Historique:
received:
10
02
2022
accepted:
05
04
2022
revised:
15
03
2022
entrez:
10
5
2022
pubmed:
11
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
The innate immune system, the primary defense mechanism of higher organisms against pathogens including viruses, senses pathogen-associated molecular patterns (PAMPs). In response to PAMPs, interferons (IFNs) are produced, allowing the host to react swiftly to viral infection. In turn the expression of IFN-stimulated genes (ISGs) is induced. Their products disseminate the antiviral response. Among the ISGs conserved in many species are those encoding mono-ADP-ribosyltransferases (mono-ARTs). This prompts the question whether, and if so how, mono-ADP-ribosylation affects viral propagation. Emerging evidence demonstrates that some mono-ADP-ribosyltransferases function as PAMP receptors and modify both host and viral proteins relevant for viral replication. Support for mono-ADP-ribosylation in virus-host interaction stems from the findings that some viruses encode mono-ADP-ribosylhydrolases, which antagonize cellular mono-ARTs. We summarize and discuss the evidence linking mono-ADP-ribosylation and the enzymes relevant to catalyze this reversible modification with the innate immune response as part of the arms race between host and viruses.
Identifiants
pubmed: 35536484
doi: 10.1007/s00018-022-04290-6
pii: 10.1007/s00018-022-04290-6
pmc: PMC9087173
doi:
Substances chimiques
Pathogen-Associated Molecular Pattern Molecules
0
ADP Ribose Transferases
EC 2.4.2.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
288Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : LU 466/16-2
Organisme : Deutsche Forschungsgemeinschaft
ID : VE 1093/1-1
Organisme : Wilhelm Sander-Stiftung
ID : 2020.034.1
Informations de copyright
© 2022. The Author(s).
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