Taste alterations during neo/adjuvant chemotherapy and subsequent follow-up in breast cancer patients: a prospective single-center clinical study.
Chemotherapy-induced toxicities
Dysgeusia
Early breast cancer
Taste alterations
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
27
10
2021
accepted:
22
04
2022
pubmed:
11
5
2022
medline:
24
6
2022
entrez:
10
5
2022
Statut:
ppublish
Résumé
Dysgeusia and taste alterations (TAs) are side effects of cytotoxic chemotherapy and affect patients' quality of life; however, the prevalence, types, and duration of TAs and their potential relationship with other clinical disturbances are not well-described. Our primary aim was to prospectively evaluate the characteristics of TAs in early breast cancer (EBC) patients during (neo)adjuvant chemotherapy and up to 1 year after its completion. From April 2014 to June 2018, 182 EBC patients entered the study and received (neo)adjuvant chemotherapy, mostly with taxane and anthracycline-containing regimens (65% of cases). A dietitian performed TAs assessment through the Common Terminology Criteria for Adverse Event v4.0 (CTCAE) and the Chemotherapy-induced Taste Alteration Scale (CiTAS) questionnaire during chemotherapy and follow-up according to defined time points: at baseline (T0, before starting chemotherapy); at the first follow-up visit, (T1, 2 months after starting chemotherapy); at the final follow-up visit (T2, 1 week after completing chemotherapy); after that, every 3 months up to 12 months. Dysgeusia was reported by 69.8% of patients at T1 and declined subsequently; salty flavor distortion was the most frequently reported TA (51.6% of cases). CiTAS was significantly different between T0 and T2 (p < 0.001). Dysgeusia occurred more frequently in patients reporting nausea, mucositis, diarrhea, and appetite modification. TAs are common but transient during chemotherapy and occurred frequently with other distressing gastrointestinal side effects. The assessment of these side effects is crucial in managing EBC patients during (neo)adjuvant chemotherapy.
Identifiants
pubmed: 35538327
doi: 10.1007/s00520-022-07091-6
pii: 10.1007/s00520-022-07091-6
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6955-6961Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Hovan AJ, Williams PM, Stevenson-Moore P et al (2010) A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer 18:1081–1087
doi: 10.1007/s00520-010-0902-1
Ponticelli E, Clari M, Frigerio S et al (2017) Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: A cross-sectional study. Eur J Cancer Care 26:e12633. https://doi.org/10.1111/ecc.12633
doi: 10.1111/ecc.12633
Gamper EM, Zabernigg A, Wintner LM et al (2012) Coming to your senses: detecting taste and smell alterations in chemotherapy patients. a systematic review. J Pain Symptom Manage 44:880–895
doi: 10.1016/j.jpainsymman.2011.11.011
Zabernigg A, Gamper E, Giesinger JM et al (2010) Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist 15:913–920. https://doi.org/10.1634/theoncologist.2009-0333
doi: 10.1634/theoncologist.2009-0333
pubmed: 20667968
pmcid: 3228016
Steinbach S, Hummel T, Böhner C et al (2009) Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies. J Clin Oncol 27:1899–1905. https://doi.org/10.1200/JCO.2008.19.2690
doi: 10.1200/JCO.2008.19.2690
pubmed: 19289621
Denda Y, Niikura N, Satoh-Kuriwada S et al (2020) Taste alterations in patients with breast cancer following chemotherapy: a cohort study. Breast Cancer 27:954–962. https://doi.org/10.1007/s12282-020-01089-w
doi: 10.1007/s12282-020-01089-w
pubmed: 32301097
Speck RM, Demichele A, Farrar JT et al (2013) Taste alteration in breast cancer patients treated with taxane chemotherapy: experience, effect, and coping strategies. Support Care Cancer 21:549–555. https://doi.org/10.1007/s00520-012-1551-3
doi: 10.1007/s00520-012-1551-3
pubmed: 22864536
Spotten L, Corish C, Lorton C et al (2016) Subjective taste and smell changes in treatment-naive people with solid tumours. Support Care Cancer 24:3201–3208. https://doi.org/10.1007/s00520-016-3133-2
doi: 10.1007/s00520-016-3133-2
pubmed: 26945569
Spotten LE, Corish CA, Lorton CM et al (2017) Subjective and objective taste and smell changes in cancer. Ann Oncol 28:969–984
doi: 10.1093/annonc/mdx018
Chaudhari N, Landin AM, Roper SD (2000) A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci 3:113–119. https://doi.org/10.1038/72053
doi: 10.1038/72053
pubmed: 10649565
Satoh-Kuriwada S, Kawai M, Iikubo M et al (2014) Development of an Umami taste sensitivity test and its clinical use. PLoS ONE 9. https://doi.org/10.1371/journal.pone.0095177
Comeau TB, Epstein JB, Migas C (2001) Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer 9
Welge-Lüssen A, Gudziol H (2004) Etiology, diagnostic and therapeutic management of taste disorders. Therapeutische Umschau 61
Halyard MY (2009) Taste and smell alterations in cancer patients—real problems with few solutions. J Support Oncol 7
Pugnaloni S, Vignini A, Borroni F et al (2020) Modifications of taste sensitivity in cancer patients: a method for the evaluations of dysgeusia. Support Care Cancer 28. https://doi.org/10.1007/s00520-019-04930-x
Wickham RS, Rehwaldt M, Kefer C et al (1999) Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 26:697–706
pubmed: 10337648
Rhodes VA, McDaniel RW, Hanson B et al (1994) Sensory perception of patients on selected antineoplastic chemotherapy protocols. Cancer Nurs 17:45–51. https://doi.org/10.1097/00002820-199402000-00005
doi: 10.1097/00002820-199402000-00005
pubmed: 8180976
IJpma I, Renken RJ, ter Horst GJ, Reyners AKL (2015) Metallic taste in cancer patients treated with chemotherapy. Cancer Treat Rev 41:179–186
doi: 10.1016/j.ctrv.2014.11.006
Henkin RI (1994) Drug-induced taste and smell disorders: incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction. Drug Saf 11:318–377
doi: 10.2165/00002018-199411050-00004
Montemurro F, Mittica G, Cagnazzo C et al (2016) Self-evaluation of adjuvant chemotherapy-related adverse effects by patients with breast cancer. JAMA Oncol 2:445–452. https://doi.org/10.1001/jamaoncol.2015.4720
doi: 10.1001/jamaoncol.2015.4720
pubmed: 26720497
Galizia D, Milani A, Geuna E et al (2018) Self-evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study. Cancer Med 7:4339–4344. https://doi.org/10.1002/cam4.1687
doi: 10.1002/cam4.1687
pubmed: 30030895
pmcid: 6144000
Pedersini R, di Mauro P, Bosio S et al (2021) Changes in eating habits and food preferences in breast cancer patients undergoing adjuvant chemotherapy. Sci Rep 11:1–10. https://doi.org/10.1038/S41598-021-92138-7
doi: 10.1038/S41598-021-92138-7
Basch E, Reeve BB, Mitchell SA, et al (2014) Development of the national cancer institute’s patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE). J Natl Cancer Inst 106
Campagna S, Gonella S, Stuardi M et al (2016) Italian validation of the chemotherapy induced taste alteration scale. Assist Inferm Ric 35:22–28. https://doi.org/10.1702/2228.24016
doi: 10.1702/2228.24016
pubmed: 27183423
Campagna S, Gonella S, Sperlinga R et al (2018) Prevalence, severity, and self-reported characteristics of taste alterations in patients receiving chemotherapy. Oncol Nurs Forum 45:342–353. https://doi.org/10.1188/18.ONF.342-353
doi: 10.1188/18.ONF.342-353
pubmed: 29683116
Kano T, Kanda K (2013) Development and validation of a chemotherapy-induced taste alteration scale. Oncol Nurs Forum 40. https://doi.org/10.1188/13.ONF.E79-E85
Boltong A, Aranda S, Keast R et al (2014) A prospective cohort study of the effects of adjuvant breast cancer chemotherapy on taste function, food liking, appetite and associated nutritional outcomes. PLoS ONE 9. https://doi.org/10.1371/journal.pone.0103512
de Vries YC, Boesveldt S, Kelfkens CS et al (2018) Taste and smell perception and quality of life during and after systemic therapy for breast cancer. Breast Cancer Res Treat 170:27–34. https://doi.org/10.1007/s10549-018-4720-3
doi: 10.1007/s10549-018-4720-3
pubmed: 29476290
pmcid: 5993854
Jensen SB, Mouridsen HT, Bergmann OJ et al (2008) Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:217–226. https://doi.org/10.1016/j.tripleo.2008.04.003
doi: 10.1016/j.tripleo.2008.04.003
pubmed: 18554960
Martini S, Iorio GC, Arcadipane F et al (2019) Prospective assessment of taste impairment and nausea during radiotherapy for head and neck cancer. Med Oncol 36. https://doi.org/10.1007/s12032-019-1269-x
Holmes S (1993) Food avoidance in patients undergoing cancer chemotherapy. Support Care Cancer 1:326–330. https://doi.org/10.1007/BF00364971
doi: 10.1007/BF00364971
pubmed: 8156251
van den Berg MMGA, Winkels RM, de Kruif JThCM et al (2017) Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer 17:259. https://doi.org/10.1186/s12885-017-3242-4
doi: 10.1186/s12885-017-3242-4
pubmed: 28403873
pmcid: 5389147
Freedman RJ, Aziz N, Albanes D et al (2004) Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J Clin Endocrinol Metab 89:2248–2253. https://doi.org/10.1210/jc.2003-031874
doi: 10.1210/jc.2003-031874
pubmed: 15126549
Heideman WH, Russell NS, Gundy C et al (2009) The frequency, magnitude and timing of post-diagnosis body weight gain in Dutch breast cancer survivors. Eur J Cancer 45:119–126. https://doi.org/10.1016/j.ejca.2008.09.003
doi: 10.1016/j.ejca.2008.09.003
pubmed: 18930387
Nolden A, Joseph PV, Kober KM et al (2019) Co-occurring gastrointestinal symptoms are associated with taste changes in oncology patients receiving chemotherapy. J Pain Symptom Manag 58:756–765. https://doi.org/10.1016/j.jpainsymman.2019.07.016
doi: 10.1016/j.jpainsymman.2019.07.016
Gamper EM, Giesinger JM, Oberguggenberger A et al (2012) Taste alterations in breast and gynaecological cancer patients receiving chemotherapy: prevalence, course of severity, and quality of life correlates. Acta Oncol 51:490–496. https://doi.org/10.3109/0284186X.2011.633554
doi: 10.3109/0284186X.2011.633554
pubmed: 22129358