Coccomyxa sp.KJ extract affects the fate of T cells stimulated by toxic shock syndrome toxin-1, a superantigen secreted by Staphylococcus aureus.
Coccomyxa
activation marker
cytokine
memory T cells
toxic shock syndrome toxin-1
Journal
Microbiology and immunology
ISSN: 1348-0421
Titre abrégé: Microbiol Immunol
Pays: Australia
ID NLM: 7703966
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
18
04
2022
received:
08
03
2022
accepted:
26
04
2022
pubmed:
12
5
2022
medline:
10
8
2022
entrez:
11
5
2022
Statut:
ppublish
Résumé
T cell stimulation by bacterial superantigens induces a cytokine storm. After T cell activation and inflammatory cytokine secretion, regulatory T cells (Treg) are produced to suppress the immune response. Coccomyxa sp.KJ (IPOD FERM BP-22254), a green alga, is reported to regulate immune reactions. Therefore, we examined the effects of Coccomyxa sp.KJ extract (CE) on the superantigen-induced immune response. When human peripheral blood mononuclear cells (PBMCs) were stimulated with toxic shock syndrome-1 (TSST-1) in the presence of CE, the number of activated T cells decreased moderately. Purified T cells stimulated in the presence of CE comprised more non-proliferating cells than those stimulated in the absence of CE, whereas some T cells proliferated more quickly. The levels of activation markers on the stimulated T cells increased in the presence of CE. Most of the inflammatory cytokines did not change but IL-1β, IL-17, IL-4, and IL-13 secretion increased, whereas that of IL-2, TNF-α, and IL-18 decreased. IL-10 secretion was also decreased by CE treatment, suggesting that the immune response was not suppressed by Treg cells. CE enhanced the expression of stem cell-like memory cell markers in T cells. These results suggest that CE can regulate the fate of T cells and can help to ameliorate superantigen-induced T cell hyperactivation and immune suppression.
Identifiants
pubmed: 35543108
doi: 10.1111/1348-0421.12982
pmc: PMC9545576
doi:
Substances chimiques
Bacterial Toxins
0
Enterotoxins
0
Superantigens
0
enterotoxin F, Staphylococcal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
394-402Subventions
Organisme : Denso Corporation
Informations de copyright
© 2022 The Authors. Microbiology and Immunology published by The Societies and John Wiley & Sons Australia, Ltd.
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