Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline.

Aging / metabolism Animals Axons / physiology CD8-Positive T-Lymphocytes / metabolism Ganglia, Spinal / metabolism Mice Nerve Regeneration Neurons / metabolism Sciatic Nerve / injuries

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
13 05 2022
Historique:
entrez: 13 5 2022
pubmed: 14 5 2022
medline: 18 5 2022
Statut: ppublish

Résumé

Aging is associated with increased prevalence of axonal injuries characterized by poor regeneration and disability. However, the underlying mechanisms remain unclear. In our experiments, RNA sequencing of sciatic dorsal root ganglia (DRG) revealed significant aging-dependent enrichment in T cell signaling both before and after sciatic nerve injury (SNI) in mice. Lymphotoxin activated the transcription factor NF-κB, which induced expression of the chemokine CXCL13 by neurons. This in turn recruited CXCR5

Identifiants

DOI: 10.1126/science.abd5926 PMID: 35549409
pubmed: 35549409
doi: 10.1126/science.abd5926
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabd5926

Subventions

Organisme : Cancer Research UK
ID : 26770
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Auteurs

Luming Zhou (L)

Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0002-7284-1744

Guiping Kong (G)

Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0001-7662-6948

Ilaria Palmisano (I)

Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0002-7139-8090

Maria Teresa Cencioni (MT)

Division of Neurology, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0002-2694-2392

Matt Danzi (M)

Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
ORCID: 0000-0003-1568-5965

Francesco De Virgiliis (F)

Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0001-7170-1013

Jessica S Chadwick (JS)

Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0001-7287-7707

Greg Crawford (G)

Department of Immunology and Inflammation, Imperial College London, London, UK.
ORCID: 0000-0002-2955-1661

Zicheng Yu (Z)

Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0003-1441-1452

Fred De Winter (F)

Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, Netherlands.
ORCID: 0000-0002-3042-2429

Vance Lemmon (V)

Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
ORCID: 0000-0003-3550-7576

John Bixby (J)

Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
ORCID: 0000-0003-1633-5318

Radhika Puttagunta (R)

Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
ORCID: 0000-0001-7674-8064

Joost Verhaagen (J)

Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, Netherlands.

Constandina Pospori (C)

Haematopoietic Stem Cell Laboratory, Francis Crick Institute, London, UK.
Department of Life Sciences, Imperial College London, South Kensington Campus, London, UK.

Cristina Lo Celso (C)

Haematopoietic Stem Cell Laboratory, Francis Crick Institute, London, UK.
Department of Life Sciences, Imperial College London, South Kensington Campus, London, UK.
ORCID: 0000-0002-1163-4207

Jessica Strid (J)

Department of Immunology and Inflammation, Imperial College London, London, UK.
ORCID: 0000-0003-3690-2201

Marina Botto (M)

Department of Immunology and Inflammation, Imperial College London, London, UK.
ORCID: 0000-0002-1458-3791

Simone Di Giovanni (S)

Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
ORCID: 0000-0003-3154-5399

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Eucaryotes › Animaux › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Cellules › Neurones › Reversible CD8 T cell-neuron cross-talk causes...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Plexus lombosacral › Nerf ischiatique › Reversible CD8 T cell-neuron cross-talk causes...