Nanomolar EP4 receptor potency and expression of eicosanoid-related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia.
Colorectal cancer
EP receptors
Lipoxygenase
Short circuit current
mRNA expression
Journal
BMC gastroenterology
ISSN: 1471-230X
Titre abrégé: BMC Gastroenterol
Pays: England
ID NLM: 100968547
Informations de publication
Date de publication:
12 May 2022
12 May 2022
Historique:
received:
29
09
2021
accepted:
27
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Aberrations in cyclooxygenase and lipoxygenase (LOX) pathways in non-neoplastic, normal appearing mucosa from patients with colorectal neoplasia (CRN), could hypothetically qualify as predisposing CRN-markers. To test this hypothesis, biopsies were obtained during colonoscopy from macroscopically normal colonic mucosa from patients with and without CRN. Prostaglandin E2 (PGE Data suggest that PGE In conclusion, normal appearing colonic mucosa from CRN patients demonstrates deviating expression in eicosanoid pathways, which might indicate a likely predisposition for early CRN development and furthermore that PGE
Sections du résumé
BACKGROUND
BACKGROUND
Aberrations in cyclooxygenase and lipoxygenase (LOX) pathways in non-neoplastic, normal appearing mucosa from patients with colorectal neoplasia (CRN), could hypothetically qualify as predisposing CRN-markers.
METHODS
METHODS
To test this hypothesis, biopsies were obtained during colonoscopy from macroscopically normal colonic mucosa from patients with and without CRN. Prostaglandin E2 (PGE
RESULTS
RESULTS
Data suggest that PGE
CONCLUSIONS
CONCLUSIONS
In conclusion, normal appearing colonic mucosa from CRN patients demonstrates deviating expression in eicosanoid pathways, which might indicate a likely predisposition for early CRN development and furthermore that PGE
Identifiants
pubmed: 35549670
doi: 10.1186/s12876-022-02311-z
pii: 10.1186/s12876-022-02311-z
pmc: PMC9097415
doi:
Substances chimiques
RNA, Messenger
0
Receptors, Prostaglandin E, EP4 Subtype
0
Cyclooxygenase 2
EC 1.14.99.1
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
234Subventions
Organisme : Lundbeckfonden
ID : R323-2018-3674
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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