Sulfated capsular polysaccharide from the marine bacterium Kangiella japonica inhibits T-47D cells growth in vitro.
Antiproliferative activity
Breast cancer
Capsular polysaccharide
Kangiella japonica
Marine bacterium
Sulfate
T-47D
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 Aug 2022
15 Aug 2022
Historique:
received:
15
03
2022
revised:
07
04
2022
accepted:
08
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
ppublish
Résumé
Kangiella japonica KMM 3897 is a Gram-negative bacterium isolated from a coastal sea-water sample of the Sea of Japan. In this paper, the results about the structure and the antiproliferative effect on cancer cells of the capsular polysaccharide isolated from the Kangiella japonica KMM 3897 have been described. The carbohydrate polymer was isolated and purified by several separation techniques, and the structure was elucidated using chemical analysis and NMR spectroscopy. The following structure of the sulfated capsular polysaccharide, containing 2-amino-2-deoxy-D-mannuronic acid was established: The capsular polysaccharide exerted a selective antiproliferative effect and suppressed the colony formation of T-47D cells.
Identifiants
pubmed: 35550752
pii: S0144-8617(22)00382-4
doi: 10.1016/j.carbpol.2022.119477
pii:
doi:
Substances chimiques
Polysaccharides
0
Sulfates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119477Informations de copyright
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