Liquid biopsy for the assessment of adrenal cancer heterogeneity: where do we stand?
Adrenocortical cancer
circulating cell-free DNA
circulating tumor cell
liquid biopsy
microRNA
temporal heterogeneity
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
06
03
2022
accepted:
27
04
2022
pubmed:
14
5
2022
medline:
20
8
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Almost 10 years have passed since the first attempts of liquid biopsy aimed at the characterisation of tumor cells present in the bloodstream from a regular sample of peripheral blood were performed. Liquid biopsy has been used to characterise tumor heterogeneity in various types of solid tumors including adrenocortical carcinoma. The development of molecular biology, genetics, and methodological advances such as digital PCR and next-generation sequencing allowed us to use besides circulating tumor cells a variety of circulating cell-free nucleic acids, DNAs, RNAs and microRNAs secreted by tumors into blood and other body fluids as specific molecular markers. These markers are used for diagnosis, to check tumor development, selecting efficient therapies, therapy monitoring and even possess prognostic power. In adrenocortical carcinoma, there are some studies reporting analysis of circulating tumor cells, circulating cell free DNA and microRNAs for assessing tumor heterogeneity. Among microRNAs, hsa-miR-483-5p seems to be the most important player. Combined with other microRNAs like hsa-miR-195, their expression correlates with recurrence-free survival. Most studies support the applicability of liquid biopsy for assessing temporal tumor heterogeneity (i.e. tumor progression) in adrenocortical cancer. In this mini-review, the available findings of liquid biopsy for assessing tumor heterogeneity in adrenocortical cancer are presented.
Identifiants
pubmed: 35552979
doi: 10.1007/s12020-022-03066-z
pii: 10.1007/s12020-022-03066-z
pmc: PMC9385753
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-431Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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