Rapid Inflammasome Activation Is Attenuated in Post-Myocardial Infarction Monocytes.
IRAKM
TNFAIP3 (A20)
acute myocardial infarction
inflammasome
interleukin 18
monocytes
refractory behavior
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
01
2022
accepted:
28
03
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
20
5
2022
Statut:
epublish
Résumé
Inflammasomes are crucial gatekeepers of the immune response, but their maladaptive activation associates with inflammatory pathologies. Besides canonical activation, monocytes can trigger non-transcriptional or rapid inflammasome activation that has not been well defined in the context of acute myocardial infarction (AMI). Rapid transcription-independent inflammasome activation induced by simultaneous TLR priming and triggering stimulus was measured by caspase-1 (CASP1) activity and interleukin release. Both classical and intermediate monocytes from healthy donors exhibited robust CASP1 activation, but only classical monocytes produced high mature interleukin-18 (IL18) release. We also recruited a limited number of coronary artery disease (CAD, n=31) and AMI (n=29) patients to evaluate their inflammasome function and expression profiles. Surprisingly, monocyte subpopulations isolated from blood collected during percutaneous coronary intervention (PCI) from AMI patients presented diminished CASP1 activity and abrogated IL18 release despite increased NLRP3 gene expression. This unexpected attenuated rapid inflammasome activation was accompanied by a significant increase of TNFAIP3 and IRAKM expression. Moreover, TNFAIP3 protein levels of circulating monocytes showed positive correlation with high sensitive troponin T (hsTnT), implying an association between TNFAIP3 upregulation and the severity of tissue injury. We suggest this monocyte attenuation to be a protective phenotype aftermath following a very early inflammatory wave in the ischemic area. Damage-associated molecular patterns (DAMPs) or other signals trigger a transitory negative feedback loop within newly recruited circulating monocytes as a mechanism to reduce post-injury tissue damage.
Identifiants
pubmed: 35558073
doi: 10.3389/fimmu.2022.857455
pmc: PMC9090500
doi:
Substances chimiques
Inflammasomes
0
Interleukin-18
0
Interleukin-1beta
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
857455Informations de copyright
Copyright © 2022 Giral, Franke, Moobed, Müller, Lübking, James, Hartung, Kuschnerus, Meteva, Seppelt, Jakob, Klingenberg, Kränkel, Leistner, Zeller, Blankenberg, Zimmermann, Haghikia, Lüscher, Akalin, Landmesser and Kratzer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Immunol. 2011 Oct 10;11(11):762-74
pubmed: 21984070
Int J Cardiol. 2017 Mar 15;231:47-53
pubmed: 28062145
Front Immunol. 2020 Sep 30;11:565924
pubmed: 33101286
Immunol Rev. 2011 Sep;243(1):163-73
pubmed: 21884175
J Immunol. 2014 Apr 15;192(8):3881-8
pubmed: 24623131
Cancer Cell. 2011 Nov 15;20(5):649-60
pubmed: 22094258
Nat Rev Immunol. 2015 Feb;15(2):117-29
pubmed: 25614321
J Immunol. 2017 Nov 15;199(10):3614-3622
pubmed: 29021376
J Cardiovasc Pharmacol. 2014 Apr;63(4):316-322
pubmed: 24336017
Front Immunol. 2013 Oct 08;4:289
pubmed: 24115947
J Exp Med. 2008 Feb 18;205(2):451-64
pubmed: 18268035
EMBO Rep. 2018 Oct;19(10):
pubmed: 30206189
Cardiovasc Res. 2013 Jul 1;99(1):164-74
pubmed: 23580606
J Immunol. 2017 Mar 1;198(5):2038-2046
pubmed: 28115526
J Biol Chem. 2009 Mar 20;284(12):7853-65
pubmed: 19164288
Nat Rev Immunol. 2017 Apr;17(4):233-247
pubmed: 28192415
Trends Cell Biol. 2015 May;25(5):308-15
pubmed: 25639489
Mediators Inflamm. 2018 May 09;2018:1752836
pubmed: 29861655
Nature. 2012 Aug 16;488(7411):389-93
pubmed: 22763455
Front Immunol. 2021 Oct 28;12:778830
pubmed: 34777396
Cell Mol Immunol. 2021 May;18(5):1141-1160
pubmed: 33850310
Nat Commun. 2016 Dec 08;7:13727
pubmed: 27929086
J Biol Chem. 2012 Oct 19;287(43):36617-22
pubmed: 22948162
Mol Med. 2014 Jun 12;20:221-9
pubmed: 24804827
PLoS One. 2014 May 05;9(5):e95073
pubmed: 24797663
Nat Med. 2017 Feb;23(2):174-184
pubmed: 28092664
J Exp Med. 2012 Jan 16;209(1):123-37
pubmed: 22213805
J Am Coll Cardiol. 2012 Oct 16;60(16):1512-20
pubmed: 22999728
Nat Med. 2015 Mar;21(3):248-55
pubmed: 25686105
Circ Res. 2017 May 26;120(11):1789-1799
pubmed: 28302649
Cardiovasc Res. 2019 Mar 15;115(4):776-787
pubmed: 30357309
Antioxid Redox Signal. 2015 May 1;22(13):1146-61
pubmed: 25330141
Nat Rev Cardiol. 2018 Apr;15(4):203-214
pubmed: 29143812
Nature. 2014 Aug 7;512(7512):69-73
pubmed: 25043000
Cell. 2002 Jul 26;110(2):191-202
pubmed: 12150927
Mol Cell. 2013 Jan 24;49(2):331-8
pubmed: 23246432
Eur Heart J. 2014 Feb;35(6):376-85
pubmed: 23966310
Circulation. 2003 Nov 18;108(20):2453-9
pubmed: 14581397
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Front Immunol. 2013 Feb 04;4:23
pubmed: 23382732
Front Immunol. 2018 Jul 30;9:1604
pubmed: 30105015
Circ Cardiovasc Genet. 2015 Oct;8(5):717-26
pubmed: 26362438
Nat Commun. 2015 Jun 10;6:7360
pubmed: 26059659
Science. 2000 Sep 29;289(5488):2350-4
pubmed: 11009421
J Clin Immunol. 1999 Jan;19(1):1-11
pubmed: 10080100
Eur Heart J. 2017 Mar 14;38(11):828-836
pubmed: 27432019
Science. 2012 Apr 27;336(6080):481-5
pubmed: 22461501
EMBO Mol Med. 2018 Feb;10(2):151-159
pubmed: 29229785
Cell. 2013 Apr 11;153(2):362-75
pubmed: 23582326
Front Immunol. 2017 Nov 08;8:1454
pubmed: 29167667
Trends Immunol. 2014 Jan;35(1):22-31
pubmed: 24246475
J Immunol. 2009 Jul 15;183(2):787-91
pubmed: 19570822
Nat Immunol. 2016 May;17(5):481-9
pubmed: 27092805
Trends Immunol. 2009 Aug;30(8):383-91
pubmed: 19643665
Science. 2013 Jan 11;339(6116):161-6
pubmed: 23307733
Cell Mol Immunol. 2017 Jan;14(1):43-64
pubmed: 27569562
Front Immunol. 2018 Apr 25;9:877
pubmed: 29922281
Science. 2007 Aug 3;317(5838):666-70
pubmed: 17673663
Cytometry A. 2016 Nov;89(11):1017-1030
pubmed: 27813253
Nat Immunol. 2008 Apr;9(4):353-9
pubmed: 18349815
Transpl Int. 2015 Dec;28(12):1436-44
pubmed: 26340315
J Biol Chem. 1992 Jun 25;267(18):12424-7
pubmed: 1618749
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2598-608
pubmed: 22995519
Immunity. 2015 Jan 20;42(1):55-67
pubmed: 25607459