Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca
calcium
cell biology
exocytosis
mouse
secretion
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
13 05 2022
13 05 2022
Historique:
received:
10
12
2021
accepted:
12
05
2022
pubmed:
14
5
2022
medline:
26
5
2022
entrez:
13
5
2022
Statut:
epublish
Résumé
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organotypic pancreatic slice. We demonstrate that the organotypic pancreatic slice, when compared with isolated islets, preserves intact β-cell structure, and enhances glucose-dependent Ca
Identifiants
pubmed: 35559734
doi: 10.7554/eLife.76262
pii: 76262
pmc: PMC9126582
doi:
pii:
Substances chimiques
Insulin
0
Integrins
0
Vesicular Transport Proteins
0
liprin alpha3 protein, mouse
0
Focal Adhesion Protein-Tyrosine Kinases
EC 2.7.10.2
Glucose
IY9XDZ35W2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Jevon et al.
Déclaration de conflit d'intérêts
DJ, KD, NH, KK, JT, WG, CT, MB, PT No competing interests declared
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