Dysregulation of organelle membrane contact sites in neurological diseases.
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
03 08 2022
03 08 2022
Historique:
received:
08
02
2022
revised:
21
03
2022
accepted:
18
04
2022
pubmed:
14
5
2022
medline:
9
8
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
The defining evolutionary feature of eukaryotic cells is the emergence of membrane-bound organelles. Compartmentalization allows each organelle to maintain a spatially, physically, and chemically distinct environment, which greatly bolsters individual organelle function. However, the activities of each organelle must be balanced and are interdependent for cellular homeostasis. Therefore, properly regulated interactions between organelles, either physically or functionally, remain critical for overall cellular health and behavior. In particular, neuronal homeostasis depends heavily on the proper regulation of organelle function and cross talk, and deficits in these functions are frequently associated with diseases. In this review, we examine the emerging role of organelle contacts in neurological diseases and discuss how the disruption of contacts contributes to disease pathogenesis. Understanding the molecular mechanisms underlying the formation and regulation of organelle contacts will broaden our knowledge of their role in health and disease, laying the groundwork for the development of new therapies targeting interorganelle cross talk and function.
Identifiants
pubmed: 35561676
pii: S0896-6273(22)00365-8
doi: 10.1016/j.neuron.2022.04.020
pmc: PMC9357093
mid: NIHMS1805445
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2386-2408Subventions
Organisme : NINDS NIH HHS
ID : R01 NS076054
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS122257
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS096241
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests S.K., R.C., and F.G. declare no competing interests. D.K. is a scientific advisor for Vanqua Bio and Intellia Therapeutics as well as a venture partner at Orbimed.
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