TMEM16 scramblases thin the membrane to enable lipid scrambling.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 05 2022
11 05 2022
Historique:
received:
04
10
2021
accepted:
25
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
TMEM16 scramblases dissipate the plasma membrane lipid asymmetry to activate multiple eukaryotic cellular pathways. Scrambling was proposed to occur with lipid headgroups moving between leaflets through a membrane-spanning hydrophilic groove. Direct information on lipid-groove interactions is lacking. We report the 2.3 Å resolution cryogenic electron microscopy structure of the nanodisc-reconstituted Ca
Identifiants
pubmed: 35562175
doi: 10.1038/s41467-022-30300-z
pii: 10.1038/s41467-022-30300-z
pmc: PMC9095706
doi:
Substances chimiques
Membrane Lipids
0
Phospholipid Transfer Proteins
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2604Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM106717
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM132081
Pays : United States
Informations de copyright
© 2022. The Author(s).
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