Resolution of Inflammation in Retinal Disorders: Briefly the State.

annexins galectins inflammation lipoxins maresins pro-resolving mediators protectins resolvins retinopathy

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Apr 2022
Historique:
received: 23 03 2022
revised: 13 04 2022
accepted: 16 04 2022
entrez: 14 5 2022
pubmed: 15 5 2022
medline: 18 5 2022
Statut: epublish

Résumé

The most frequent retinal diseases, such as diabetic retinopathy, age-related macular degeneration and posterior uveitis, are underlined by oxidative stress or aging-induced retinal inflammation, which contributes to vision impairing or loss. Resolution of inflammation is emerging as a critical phase able to counteract the inflammatory process leading to the progression of retinal damage. Particularly, pro-resolving mediators (PMs) play a key role in the modulation of inflammatory exudates and could be considered a new target to be investigated in different inflammatory-autoimmune pathologies. Here, we highlight the most recent studies concerning the role of the main PMs (lipoxins, resolvins, prtectins, maresins and annexins) in retinal inflammation, in order to collect the best evidence in the field of inflammatory retinal damage resolution and to propose novel pharmacological approaches in the management of the most common retinal diseases.

Identifiants

pubmed: 35562891
pii: ijms23094501
doi: 10.3390/ijms23094501
pmc: PMC9100636
pii:
doi:

Substances chimiques

Inflammation Mediators 0
Lipoxins 0
Docosahexaenoic Acids 25167-62-8

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : ITALIAN MINISTRY OF EDUCATION, UNIVERSITY AND RESEARCH
ID : PRIN-2017TSHBXZ
Organisme : ROMANIAN MINISTRY OF RESEARCH, INNOVATION AND DIGITIZATION, CNCS/CCCDI - UEFISCDI
ID : PN-III-P4-ID-PCE-2020-1772, within PNCDI III.

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Auteurs

Maria Consiglia Trotta (MC)

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.

Carlo Gesualdo (C)

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 6, 80131 Naples, Italy.

Francesco Petrillo (F)

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.

Caterina Claudia Lepre (CC)

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.

Alberto Della Corte (A)

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 6, 80131 Naples, Italy.

Giancuomo Cavasso (G)

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 6, 80131 Naples, Italy.

Giulia Maggiore (G)

Department of Ophthalmology, University of Foggia, Viale Luigi Pinto 1, 71122 Foggia, Italy.

Anca Hermenean (A)

"Aurel Ardelean" Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310414 Arad, Romania.

Francesca Simonelli (F)

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 6, 80131 Naples, Italy.

Michele D'Amico (M)

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.

Settimio Rossi (S)

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 6, 80131 Naples, Italy.

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