Design of DNA Intercalators Based on 4-Carboranyl-1,8-Naphthalimides: Investigation of Their DNA-Binding Ability and Anticancer Activity.
Antineoplastic Agents
/ chemistry
Apoptosis
Cell Line, Tumor
DNA
/ metabolism
DNA Topoisomerases, Type II
/ metabolism
Intercalating Agents
/ chemistry
Molecular Structure
Naphthalimides
/ chemistry
Reactive Oxygen Species
/ pharmacology
Structure-Activity Relationship
Topoisomerase II Inhibitors
/ pharmacology
1,8-naphthalimides
anticancer activity
carborane
intercalators
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Apr 2022
21 Apr 2022
Historique:
received:
25
03
2022
revised:
12
04
2022
accepted:
19
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
In the present study, we continue our work related to the synthesis of 1,8-naphthalimide and carborane conjugates and the investigation of their anticancer activity and DNA-binding ability. For this purpose, a series of 4-carboranyl-1,8-naphthalimide derivatives, mitonafide, and pinafide analogs were synthesized using click chemistry, reductive amination, amidation, and Mitsunobu reactions. The calf thymus DNA (ct-DNA)-binding properties of the synthesized compounds were investigated by circular dichroism (CD), UV-vis spectroscopy, and thermal denaturation experiments. Conjugates
Identifiants
pubmed: 35562989
pii: ijms23094598
doi: 10.3390/ijms23094598
pmc: PMC9101373
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Intercalating Agents
0
Naphthalimides
0
Reactive Oxygen Species
0
Topoisomerase II Inhibitors
0
DNA
9007-49-2
DNA Topoisomerases, Type II
EC 5.99.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Centre, Poland
ID : 2014/14/E/ST5/00577
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