Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation.
MIF
T cells
inflammation
kidney diseases
macrophages
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Apr 2022
28 Apr 2022
Historique:
received:
03
04
2022
revised:
26
04
2022
accepted:
26
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells. MIF is released from the diseased kidney immediately upon stimulation to trigger renal inflammation by activating macrophages and T cells, and promoting the production of proinflammatory cytokines, chemokines, and stress molecules via signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling. In addition, MIF can function as a stress molecule to counter-regulate the immunosuppressive effect of glucocorticoid in renal inflammation. Given the critical position of MIF in the upstream inflammatory cascade, this review focuses on the regulatory role and molecular mechanisms of MIF in kidney diseases. The therapeutic potential of targeting MIF signaling to treat kidney diseases is also discussed.
Identifiants
pubmed: 35563296
pii: ijms23094908
doi: 10.3390/ijms23094908
pmc: PMC9102975
pii:
doi:
Substances chimiques
Histocompatibility Antigens Class II
0
Macrophage Migration-Inhibitory Factors
0
Receptors, Interleukin-8B
0
Intramolecular Oxidoreductases
EC 5.3.-
MIF protein, human
EC 5.3.2.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Research Grants of Council of Hong Kong
ID : 14117418, 14104019, 14101121
Organisme : Lui Che Woo Institute of Innovative Medicine
ID : (CARE program)
Organisme : National Natural Science Foundation of China Grant
ID : 82100736
Organisme : Postdoctoral Science Foundation of China grant
ID : 2021M700778
Organisme : Deng Feng Program of Foshan
ID : 2019A007, 2020A017
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