Effects of Pituitary Adenylate Cyclase Activating Polypeptide on Cell Death.
PACAP
apoptosis
cell death
in vitro
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Apr 2022
29 Apr 2022
Historique:
received:
30
03
2022
revised:
25
04
2022
accepted:
28
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated as a hypothalamic peptide based on its efficacy to increase adenylate cyclase (AC) activity. It has a widespread distribution throughout the body including the nervous system and peripheral organs, where PACAP exerts protective effects both in vivo and in vitro through its anti-apoptotic, anti-inflammatory, and antioxidant functions. The aim of the present paper was to review the currently available literature regarding the effects of PACAP on cell death in vitro in neural and non-neural cells. Among others, its effect on apoptosis can be detected in cerebellar granule cells against different toxic stimuli. Different neural cell types from the cerebral cortex are also prevented from cell death. PACAP also shows effects on cell death in cells belonging to the peripheral nervous system and protects both neural and non-neural cells of sensory organs. In addition, cell survival-promoting effect can be observed in different peripheral organ systems including cardiovascular, immune, respiratory, gastrointestinal, urinary, and reproductive systems. The studies summarized here indicate its noteworthy effect on cell death in different in vitro models, suggesting PACAP's potential therapeutic usage in several pathological conditions.
Identifiants
pubmed: 35563353
pii: ijms23094953
doi: 10.3390/ijms23094953
pmc: PMC9100246
pii:
doi:
Substances chimiques
Pituitary Adenylate Cyclase-Activating Polypeptide
0
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Thematic Excellence Program 2021 Health Sub-programme of the Ministry for Innovation and Technology, Hungary
ID : EGA-16
Organisme : National Research, Development and Innovation Fund, Hungary
ID : FK129190
Organisme : National Research, Development and Innovation Fund, Hungary
ID : K119759
Organisme : National Research, Development and Innovation Fund, Hungary
ID : K135457
Organisme : National Brain Research Program, Hungary
ID : NAP2017-1.2.1-NKP-2017-00002
Organisme : Hungarian Academy of Sciences
ID : MTA-TKI-14016
Organisme : Hungarian Government
ID : GINOP-2.3.2-15-2016-00050 "PEPSYS"
Organisme : Ministry of Human Capacities, Hungary
ID : Higher Education Institutional Excellence Program
Organisme : Ministry of Human Capacities, Hungary
ID : 20765/3/2018/FEKUTSTRAT
Organisme : National Research, Development and Innovation Fund, Hungary
ID : 2020-4.1.1-TKP2020-FIKP III. Project No. TKP2020-IKA-08
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