Angiotensin II Promotes SARS-CoV-2 Infection via Upregulation of ACE2 in Human Bronchial Cells.
COVID-19
angiotensin II
angiotensin receptor blocker
angiotensin-converting enzyme 2
angiotensin-converting enzyme inhibitor
severe acute respiratory syndrome coronavirus 2
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 May 2022
04 May 2022
Historique:
received:
28
03
2022
revised:
01
05
2022
accepted:
02
05
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Blockers of the renin-angiotensin system (RAS) have been reported to increase the angiotensin converting enzyme (ACE)2, the cellular receptor of SARS-CoV-2, and thus the risk and course of COVID-19. Therefore, we investigated if angiotensin (Ang) II and RAS blockers affected ACE2 expression and SARS-CoV-2 infectivity in human epithelial bronchial Calu-3 cells. By infectivity and spike-mediated cell-cell fusion assays, we showed that Ang II acting on the angiotensin type 1 receptor markedly increased
Identifiants
pubmed: 35563515
pii: ijms23095125
doi: 10.3390/ijms23095125
pmc: PMC9102833
pii:
doi:
Substances chimiques
Angiotensin Receptor Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Receptor, Angiotensin, Type 1
0
Angiotensin II
11128-99-7
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Intesa San Paolo
ID : B/2020/0138 "INTENTION"
Organisme : SEED 2020
ID : n/a
Organisme : FORICA (The Foundation for advanced Research In Hypertension and Cardiovascular diseases, foricaonlus.com
ID : n/a
Organisme : "Emergenza Covid 19" U-GOV
ID : CALI_PRIV20_01
Organisme : CARIPARO
ID : 55813, "COVID_DIMED"
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