Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8

Animals Antigen Presentation CD8-Positive T-Lymphocytes Cross-Priming Epithelial Cells / metabolism Kidney Tubules, Proximal / metabolism Mice
antigen cross-presentation apoptosis cytotoxic CD8+ T cells lupus nephritis proximal tubular epithelial cells

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
30 04 2022
Historique:
received: 08 04 2022
revised: 24 04 2022
accepted: 28 04 2022
entrez: 14 5 2022
pubmed: 15 5 2022
medline: 18 5 2022
Statut: epublish

Résumé

Immune-mediated glomerular diseases are characterized by infiltration of T cells, which accumulate in the periglomerular space and tubulointerstitium in close contact to proximal and distal tubuli. Recent studies described proximal tubular epithelial cells (PTECs) as renal non-professional antigen-presenting cells that stimulate CD4

Identifiants

DOI: 10.3390/cells11091510 PMID: 35563816 PMC: PMC9104549
pubmed: 35563816
pii: cells11091510
doi: 10.3390/cells11091510
pmc: PMC9104549
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Alexandra Linke (A)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
ORCID: 0000-0002-2831-0647

Hakan Cicek (H)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Anne Müller (A)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Catherine Meyer-Schwesinger (C)

Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Simon Melderis (S)

Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
III. Medical Clinic, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Thorsten Wiech (T)

Institute of Pathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
ORCID: 0000-0003-4053-1474

Claudia Wegscheid (C)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
ORCID: 0000-0001-9905-6386

Julius Ridder (J)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Oliver M Steinmetz (OM)

Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
III. Medical Clinic, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Linda Diehl (L)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Gisa Tiegs (G)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Katrin Neumann (K)

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antigen Cross-Presentation by Murine Proximal...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Présentation d'antigène › Antigen Cross-Presentation by Murine Proximal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Antigen Cross-Presentation by Murine Proximal...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Cross-priming › Antigen Cross-Presentation by Murine Proximal...
questionsmedicales.fr › Cellules › Cellules épithéliales › Antigen Cross-Presentation by Murine Proximal...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Tubules rénaux › Tubules contournés proximaux › Antigen Cross-Presentation by Murine Proximal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Antigen Cross-Presentation by Murine Proximal...