Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells.


Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
07 May 2022
Historique:
received: 05 04 2022
revised: 03 05 2022
accepted: 04 05 2022
entrez: 14 5 2022
pubmed: 15 5 2022
medline: 18 5 2022
Statut: epublish

Résumé

1,8-naphthyridine-3-carboxamide structures were previously identified as a promising scaffold from which to obtain CB2R agonists with anticancer and anti-inflammatory activity. This work describes the synthesis and functional characterization of new 1,8-naphthyridin-2(1

Identifiants

pubmed: 35566369
pii: molecules27093019
doi: 10.3390/molecules27093019
pmc: PMC9101764
pii:
doi:

Substances chimiques

Cannabinoid Receptor Agonists 0
Cannabinoids 0
Receptor, Cannabinoid, CB1 0
Receptor, Cannabinoid, CB2 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

J Med Chem. 2009 Jun 25;52(12):3644-51
pubmed: 19435366
Sci Rep. 2017 Feb 13;7:42157
pubmed: 28191815
FEBS J. 2013 Dec;280(23):6223-32
pubmed: 24112551
Mol Med Rep. 2019 Dec;20(6):5100-5110
pubmed: 31661120
J Biol Chem. 2006 Dec 22;281(51):39480-91
pubmed: 17068343
Sci Rep. 2020 Nov 23;10(1):20405
pubmed: 33230154
Biochim Biophys Acta Proteins Proteom. 2019 Jun;1867(6):637-644
pubmed: 30710643
Cell Tissue Res. 2018 May;372(2):277-286
pubmed: 29305654
Breast Cancer (Dove Med Press). 2016 Apr 15;8:59-71
pubmed: 27186076
Nat Rev Cancer. 2013 Jun;13(6):397-411
pubmed: 23702928
Nat Genet. 2015 Aug;47(8):864-71
pubmed: 26121087
Molecules. 2021 Dec 23;27(1):
pubmed: 35011295
Cell Mol Life Sci. 2016 Dec;73(23):4449-4470
pubmed: 27402121
Lancet. 2007 Jun 23;369(9579):2106-20
pubmed: 17586306
Eur J Med Chem. 2012 Jun;52:284-94
pubmed: 22483967
Nat Commun. 2020 Jan 3;11(1):71
pubmed: 31900415
Cell Death Dis. 2015 Oct 15;6:e1909
pubmed: 26469958
Oncoscience. 2015 Feb 09;2(2):131-41
pubmed: 25859556
Arch Pharm (Weinheim). 2015 Dec;348(12):837-60
pubmed: 26548568
Neuropsychiatr Dis Treat. 2008 Oct;4(5):847-53
pubmed: 19183777
Drug Des Devel Ther. 2019 Oct 11;13:3539-3550
pubmed: 31631978
Eur J Med Chem. 2017 Mar 31;129:12-26
pubmed: 28219046
Bioorg Chem. 2021 Mar;108:104586
pubmed: 33607574
Cancer Genet Cytogenet. 2006 Nov;171(1):31-8
pubmed: 17074588
Front Oncol. 2019 Jul 12;9:564
pubmed: 31355131
J Mol Neurosci. 2016 Apr;58(4):441-5
pubmed: 26842917
Mol Cancer Ther. 2009 Nov;8(11):3117-29
pubmed: 19887554
J Med Chem. 2014 Nov 13;57(21):8777-91
pubmed: 25272206
PLoS One. 2013 May 01;8(5):e62511
pubmed: 23658734
Int J Mol Sci. 2018 Jul 04;19(7):
pubmed: 29973514
FEBS J. 2013 May;280(9):1918-43
pubmed: 23551849
J Cancer Res Ther. 2012 Oct-Dec;8(4):549-54
pubmed: 23361273
Neuropharmacology. 2004;47 Suppl 1:345-58
pubmed: 15464149

Auteurs

Francesca Gado (F)

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

Rebecca Ferrisi (R)

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

Sarah Di Somma (S)

Department of Translational Medical Sciences, University of Naples Federico II, 80131 Napoli, Italy.

Fabiana Napolitano (F)

Department of Translational Medical Sciences, University of Naples Federico II, 80131 Napoli, Italy.

Kawthar A Mohamed (KA)

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

Lesley A Stevenson (LA)

Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Simona Rapposelli (S)

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

Giuseppe Saccomanni (G)

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

Giuseppe Portella (G)

Department of Translational Medical Sciences, University of Naples Federico II, 80131 Napoli, Italy.

Roger G Pertwee (RG)

Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Robert B Laprairie (RB)

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Department of Pharmacology, College of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada.

Anna Maria Malfitano (AM)

Department of Translational Medical Sciences, University of Naples Federico II, 80131 Napoli, Italy.

Clementina Manera (C)

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

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Classifications MeSH