A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin
LC-MS/MS
liquid-liquid extraction
protein precipitation
thia-analogous indirubin N-glycosides
validation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 May 2022
09 May 2022
Historique:
received:
04
02
2022
revised:
16
03
2022
accepted:
17
03
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Indirubin was identified as an active component of Danggui Longhui Wan, an herbal mixture used in traditional Chinese medicine, and showed anticancer activity in clinical trials in patients with chronic leukemia. Investigations on the mechanisms of antitumor action of indirubins have mainly focused on the indirubin derivative indirubin-3'-monoxime (I3M). Meanwhile, antiproliferative and cytotoxic properties on cancer cells have also been demonstrated for several synthetic indirubin
Identifiants
pubmed: 35566381
pii: molecules27093031
doi: 10.3390/molecules27093031
pmc: PMC9101087
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Glycosides
0
Indoles
0
Oximes
0
Oxindoles
0
indirubin-3'-monoxime
0
indirubin
V86L8P74GI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Social Fund, reference: ESF/14-BM-A55-0002/18, and the Ministry of Education, Science and Culture of Mecklenburg-Vorpommern, Germany.
ID : reference: ESF/14-BM-A55-0002/18
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