Evidence for a Role of CCR6+ T Cells in Chronic Thromboembolic Pulmonary Hypertension.
CCR6
CTLA4
T cell
chronic thromboembolic pulmonary hypertension
cytokine
immunology
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
01
2022
accepted:
29
03
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Previous studies have shown an increase of T cells and chemokines in vascular lesions of patients with chronic thromboembolic pulmonary hypertension (CTEPH). However, detailed characterization of these T cells is still lacking, nor have treatment effects been evaluated. We included 41 treatment-naive CTEPH patients at diagnosis, 22 patients at 1-year follow-up, and 17 healthy controls (HCs). Peripheral blood T cells were characterized by flow cytometry for subset distribution, cytokine expression and activation marker profile. We used multiplex immunofluorescence to identify CCR6 At diagnosis, proportions of CCR6 The observed increase of CCR6
Identifiants
pubmed: 35572511
doi: 10.3389/fimmu.2022.861450
pmc: PMC9094486
doi:
Substances chimiques
CCR6 protein, human
0
CTLA-4 Antigen
0
Cytokines
0
Interleukin-17
0
Receptors, CCR6
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
861450Informations de copyright
Copyright © 2022 van Uden, Koudstaal, van Hulst, van den Bosch, Vink, Bergen, Lila, van den Bosch, Bresser, Kool, von der Thüsen, Hendriks and Boomars.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Scand Cardiovasc J. 2016 Aug;50(4):243-50
pubmed: 27146648
Arthritis Res Ther. 2021 Jun 3;23(1):157
pubmed: 34082814
Eur Respir J. 2018 Sep 16;52(3):
pubmed: 30002102
Nat Rev Immunol. 2022 Apr;22(4):251-265
pubmed: 34389841
Circulation. 2010 Aug 31;122(9):920-7
pubmed: 20713898
Respir Res. 2009 Jan 27;10:6
pubmed: 19173740
Eur Respir Rev. 2010 Mar;19(115):59-63
pubmed: 20956167
Thorax. 2021 Dec;76(12):1209-1218
pubmed: 33963088
Immunol Rev. 2008 Jun;223:87-113
pubmed: 18613831
J Clin Med. 2020 Feb 19;9(2):
pubmed: 32092864
Circ Res. 2009 Jan 30;104(2):236-44, 28p following 244
pubmed: 19074475
ERJ Open Res. 2021 Aug 16;7(3):
pubmed: 34409094
Am J Respir Crit Care Med. 2012 Feb 1;185(3):311-21
pubmed: 22108206
Eur Respir J. 2014 Oct;44(4):951-62
pubmed: 25034560
Exp Cell Res. 2021 Oct 15;407(2):112801
pubmed: 34461107
Chest. 2015 Jun;147(6):1610-1620
pubmed: 25429518
Aging (Albany NY). 2021 Jun 21;13(12):16485-16499
pubmed: 34153003
Circulation. 2016 May 3;133(18):1761-71
pubmed: 27052413
Circulation. 2016 Mar 1;133(9):859-71
pubmed: 26826181
Intern Med. 2020;59(15):1819-1826
pubmed: 32741891
J Immunol. 2009 Feb 15;182(4):1794-8
pubmed: 19201830
Sci Immunol. 2021 Jan 29;6(55):
pubmed: 33514640
Nat Rev Immunol. 2013 Apr;13(4):227-42
pubmed: 23470321
J Thromb Thrombolysis. 2016 Jul;42(1):38-45
pubmed: 26667361
Am Heart J. 2019 Feb;208:91-99
pubmed: 30580131
Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2078-87
pubmed: 27470511
Circulation. 2009 Mar 17;119(10):1424-32
pubmed: 19255340
Heart. 2002 Aug;88(2):177-82
pubmed: 12117850
Circ Res. 2016 Feb 19;118(4):692-702
pubmed: 26892967
Circulation. 2011 May 31;123(21):e614; author reply e615
pubmed: 21632514
Chest. 2004 Jul;126(1):135-41
pubmed: 15249454
Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L870-8
pubmed: 19286928
Hypertension. 2000 Aug;36(2):282-90
pubmed: 10948091
Respir Res. 2016 Feb 29;17:21
pubmed: 26927848
Eur Respir J. 2015 Oct;46(4):903-75
pubmed: 26318161
Int J Mol Sci. 2021 Feb 10;22(4):
pubmed: 33578743
Blood. 2021 Feb 25;137(8):1104-1116
pubmed: 33512471
Immunol Lett. 2016 Oct;178:20-6
pubmed: 27173097
Thromb Haemost. 2017 Apr 3;117(4):769-783
pubmed: 28150849
J Autoimmun. 2018 Feb;87:1-15
pubmed: 29275836
J Interferon Cytokine Res. 2009 Jun;29(6):313-26
pubmed: 19441883
J Clin Med. 2021 Mar 01;10(5):
pubmed: 33804413
Eur J Immunol. 2012 Dec;42(12):3180-8
pubmed: 22965818
J Immunol. 2010 Nov 15;185(10):5820-7
pubmed: 20952673
Immunology. 2001 Jun;103(2):131-6
pubmed: 11412299
Nat Rev Cardiol. 2017 Oct;14(10):603-614
pubmed: 28593996
Eur Respir Rev. 2017 Mar 29;26(143):
pubmed: 28356405
Respir Res. 2021 May 4;22(1):137
pubmed: 33947407
Eur Respir J. 2015 Aug;46(2):431-43
pubmed: 26113681
Eur Respir J. 2021 Jun 17;57(6):
pubmed: 33334946
Retrovirology. 2016 Aug 24;13(1):59
pubmed: 27553844
Pulm Circ. 2016 Jun;6(2):145-54
pubmed: 27252839
Autoimmun Rev. 2021 Jul;20(7):102846
pubmed: 33971346