ASC nanobodies to counteract the consequences of inflammasome activation.
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
08 06 2022
08 06 2022
Historique:
revised:
03
05
2022
received:
25
04
2022
accepted:
03
05
2022
pubmed:
17
5
2022
medline:
10
6
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
Inflammasomes are multiprotein complexes that signal by oligomerizing the apoptosis speck-like protein with caspase recruitment and activator domain (ASC) and are involved in multiple inflammatory, metabolic and degenerative diseases. Pharmacological targeting of specific inflammasomes with small molecules is leading to the development of novel drugs for most common diseases. The targeting of ASC oligomers will result in a pan-inflammasome treatment. In their study, Bertheloot et al (2022) developed specific anti-ASC nanobodies and showed their efficacy to disaggregate already formed ASC oligomers and to treat inflammatory diseases in animal models. This approach represents a novel biologic-based treatment for inflammasomes-initiated inflammatory diseases.
Identifiants
pubmed: 35574976
doi: 10.15252/emmm.202216087
pmc: PMC9174878
doi:
Substances chimiques
CARD Signaling Adaptor Proteins
0
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Single-Domain Antibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e16087Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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EMBO Mol Med. 2022 Jun 8;14(6):e16087
pubmed: 35574976