Pablo Pelegrin

Affiliations

Molecular Inflammation Group, Biomedical Research Institute of Murcia, Clinical University Hospital Virgen de la Arrixaca (IMIB-Arrixaca), Carretera Buenavista s/n, Murcia 30120, Spain.

Publications (24)

Cardiolipin in Immune Signaling and Cell Death.

Trends in cell biology

Impact of Immune Response in Short-term and Long-term Outcomes After Minimally Invasive Surgery for Colorectal Liver Metastases: Results From a Randomized Study.

Surgical laparoscopy, endoscopy & percutaneous techniques

Avec: Victor Lopez-Lopez , Alvaro Gómez Ruiz , Pablo Pelegrin , Beatriz Abellán , Asunción Lopez-Conesa , Roberto Brusadin , Valentin Cayuela , Ana García , Ricardo Robles Campos

Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects.

Scientific reports

Avec: Susanne Gaul , Karen Marie Schaeffer , Lena Opitz , Christina Maeder , Alexander Kogel , Luisa Uhlmann , Hermann Kalwa , Ulf Wagner , Jan Haas , Amirhossein Behzadi , Pablo Pelegrin , Jes-Niels Boeckel , Ulrich Laufs

The prognostic impact of SIGLEC5-induced impairment of CD8

EBioMedicine

Avec: Roberto Lozano-Rodríguez , José Avendaño-Ortíz , Karla Montalbán-Hernández , Juan Carlos Ruiz-Rodríguez , Ricardo Ferrer , Alejandro Martín-Quirós , Charbel Maroun-Eid , Juan José González-López , Anna Fàbrega , Verónica Terrón-Arcos , María Gutiérrez-Fernández , Elisa Alonso-López , Carolina Cubillos-Zapata , María Fernández-Velasco , Rebeca Pérez de Diego , Pablo Pelegrin , Carlos García-Palenciano , Francisco J Cueto , Carlos Del Fresno , Eduardo López-Collazo

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.

Nature communications

Avec: Juan José Martínez-García , Helios Martínez-Banaclocha , Diego Angosto-Bazarra , Carlos de Torre-Minguela , Alberto Baroja-Mazo , Cristina Alarcón-Vila , Laura Martínez-Alarcón , Joaquín Amores-Iniesta , Fátima Martín-Sánchez , Giovanni A Ercole , Carlos M Martínez , Ada González-Lisorge , José Fernández-Pacheco , Piedad Martínez-Gil , Sahil Adriouch , Friedrich Koch-Nolte , Juan Luján , Francisco Acosta-Villegas , Pascual Parrilla , Carlos García-Palenciano , Pablo Pelegrin

Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4.

Cellular and molecular life sciences : CMLS

Avec: Malvina Pizzuto , Caroline Lonez , Alberto Baroja-Mazo , Helios Martínez-Banaclocha , Panagiotis Tourlomousis , Monique Gangloff , Pablo Pelegrin , Jean-Marie Ruysschaert , Nicholas J Gay , Clare E Bryant

NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodelling in a mouse model of diet-induced obesity.

British journal of pharmacology

Avec: Carolina Pellegrini , Matteo Fornai , Laura Benvenuti , Rocchina Colucci , Valentina Caputi , Pablo Palazon-Riquelme , Maria Cecilia Giron , Anna Nericcio , Francesca Garelli , Vanessa D'Antongiovanni , Cristina Segnani , Chiara Ippolito , Monica Nannipieri , Gloria Lopez-Castejon , Pablo Pelegrin , György Haskó , Nunzia Bernardini , Corrado Blandizzi , Luca Antonioli

Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity.

Frontiers in immunology

Avec: Julio García-Villalba , Laura Hurtado-Navarro , Alejandro Peñín-Franch , Cristina Molina-López , Laura Martínez-Alarcón , Diego Angosto-Bazarra , Alberto Baroja-Mazo , Pablo Pelegrin

Ornithine lipid is a partial TLR4 agonist and NLRP3 activator.

Cell reports

Avec: Malvina Pizzuto , Laura Hurtado-Navarro , Cristina Molina-Lopez , Jalal Soubhye , Michel Gelbcke , Silvia Rodriguez-Lopez , Jean-Marie Ruysschaert , Kate Schroder , Pablo Pelegrin

Increased NLRP3 Inflammasome Activation and Pyroptosis in Patients With Multiple Sclerosis With Fingolimod Treatment Failure.

Neurology(R) neuroimmunology & neuroinflammation

Avec: Sunny Malhotra , Laura Hurtado-Navarro , Agustin Pappolla , Luisa M M Villar , Jordi Río , Xavier Montalban , Pablo Pelegrin , Manuel Comabella

Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production.

Nature communications

Avec: Cristina Molina-López , Laura Hurtado-Navarro , Carlos J García , Diego Angosto-Bazarra , Fernando Vallejo , Ana Tapia-Abellán , Joana R Marques-Soares , Carmen Vargas , Segundo Bujan-Rivas , Francisco A Tomás-Barberán , Juan I Arostegui , Pablo Pelegrin

MCC950 closes the active conformation of NLRP3 to an inactive state.

Nature chemical biology

Avec: Ana Tapia-Abellán , Diego Angosto-Bazarra , Helios Martínez-Banaclocha , Carlos de Torre-Minguela , Jose P Cerón-Carrasco , Horacio Pérez-Sánchez , Juan I Arostegui , Pablo Pelegrin

NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients.

Brain : a journal of neurology

Avec: Sunny Malhotra , Carme Costa , Herena Eixarch , Christian W Keller , Lukas Amman , Helios Martínez-Banaclocha , Luciana Midaglia , Eduard Sarró , Isabel Machín-Díaz , Luisa M Villar , Juan Carlos Triviño , Begoña Oliver-Martos , Laura Navarro Parladé , Laura Calvo-Barreiro , Fuencisla Matesanz , Koen Vandenbroeck , Elena Urcelay , María-Luisa Martínez-Ginés , Amalia Tejeda-Velarde , Nicolás Fissolo , Joaquín Castilló , Alex Sanchez , Avril A B Robertson , Diego Clemente , Marco Prinz , Pablo Pelegrin , Jan D Lünemann , Carmen Espejo , Xavier Montalban , Manuel Comabella

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.

Cell

Avec: Liudmila Andreeva , Liron David , Shaun Rawson , Chen Shen , Teerithveen Pasricha , Pablo Pelegrin , Hao Wu

Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state.

Nature chemical biology

Avec: Ana Tapia-Abellán , Diego Angosto-Bazarra , Helios Martínez-Banaclocha , Carlos de Torre-Minguela , Jose P Cerón-Carrasco , Horacio Pérez-Sánchez , Juan I Arostegui , Pablo Pelegrin

ASC nanobodies to counteract the consequences of inflammasome activation.

EMBO molecular medicine

Avec: Sahil Adriouch , Pablo Pelegrin

Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome.

Progress in lipid research

Avec: Malvina Pizzuto , Pablo Pelegrin , Jean-Marie Ruysschaert

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.

Journal of hepatology

Avec: Susanne Gaul , Aleksandra Leszczynska , Fernando Alegre , Benedikt Kaufmann , Casey D Johnson , Leon A Adams , Alexander Wree , Georg Damm , Daniel Seehofer , Carolina J Calvente , Davide Povero , Tatiana Kisseleva , Akiko Eguchi , Matthew D McGeough , Hal M Hoffman , Pablo Pelegrin , Ulrich Laufs , Ariel E Feldstein

Correction to: Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4.

Cellular and molecular life sciences : CMLS

CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis.

eLife

Avec: Cristina Alarcón-Vila , Alberto Baroja-Mazo , Carlos de Torre-Minguela , Carlos M Martínez , Juan J Martínez-García , Helios Martínez-Banaclocha , Carlos García-Palenciano , Pablo Pelegrin

P2X7 receptor and the NLRP3 inflammasome: Partners in crime.

Biochemical pharmacology

Avec: Pablo Pelegrin

Early-onset recurrent panniculitis as a phenotype of NLRC4-associated autoinflammatory syndrome: Characterization of pathogenicity of the p.Ser445Pro NLRC4 variant.

The Australasian journal of dermatology

Avec: Javier Gil-Lianes , Giuseppe Gariup , Pilar Iranzo-Fernández , Anna Mensa-Vilaró , Alejandro Peñín-Franch , Laura Hurtado-Navarro , Pablo Pelegrin , Juan I Aróstegui

ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux.

The Journal of cell biology

Avec: Fátima Martín-Sánchez , Vincent Compan , Alejandro Peñín-Franch , Ana Tapia-Abellán , Ana I Gómez , María C Baños-Gregori , Florian I Schmidt , Pablo Pelegrin

Multiple ASC-dependent inflammasomes drive differential pro-inflammatory cytokine production in a mouse model of tendinopathy.

Bioscience reports

Avec: Alejandro Peñín-Franch , Laura Hurtado-Navarro , Jose Antonio García-Vidal , Pilar Escolar-Reina , Francesc Medina-Mirapeix , Pablo Pelegrin

Réseau de co-auteurs

Helios Martínez-Banaclocha 7 collaborations

Laura Hurtado-Navarro 6 collaborations

Malvina Pizzuto 5 collaborations

Diego Angosto-Bazarra 5 collaborations

Alberto Baroja-Mazo 5 collaborations

Carlos de Torre-Minguela 4 collaborations

Jean-Marie Ruysschaert 4 collaborations

Alejandro Peñín-Franch 4 collaborations

Ana Tapia-Abellán 4 collaborations

Carlos García-Palenciano 3 collaborations

Juan I Arostegui 3 collaborations

Susanne Gaul 2 collaborations

Ulrich Laufs 2 collaborations

Cristina Alarcón-Vila 2 collaborations

Laura Martínez-Alarcón 2 collaborations

Fátima Martín-Sánchez 2 collaborations

Carlos M Martínez 2 collaborations

Sahil Adriouch 2 collaborations

Caroline Lonez 2 collaborations

Panagiotis Tourlomousis 2 collaborations

Monique Gangloff 2 collaborations

Nicholas J Gay 2 collaborations

Clare E Bryant 2 collaborations

Cristina Molina-López 2 collaborations

Sunny Malhotra 2 collaborations

Xavier Montalban 2 collaborations

Manuel Comabella 2 collaborations

Jose P Cerón-Carrasco 2 collaborations

Horacio Pérez-Sánchez 2 collaborations

Victor Lopez-Lopez 1 collaboration

Alvaro Gómez Ruiz 1 collaboration

Beatriz Abellán 1 collaboration

Asunción Lopez-Conesa 1 collaboration

Roberto Brusadin 1 collaboration

Valentin Cayuela 1 collaboration

Ana García 1 collaboration

Ricardo Robles Campos 1 collaboration

Karen Marie Schaeffer 1 collaboration

Lena Opitz 1 collaboration

Christina Maeder 1 collaboration

Alexander Kogel 1 collaboration

Luisa Uhlmann 1 collaboration

Hermann Kalwa 1 collaboration

Ulf Wagner 1 collaboration

Jan Haas 1 collaboration

Amirhossein Behzadi 1 collaboration

Jes-Niels Boeckel 1 collaboration

Roberto Lozano-Rodríguez 1 collaboration

José Avendaño-Ortíz 1 collaboration

Karla Montalbán-Hernández 1 collaboration

Juan Carlos Ruiz-Rodríguez 1 collaboration

Ricardo Ferrer 1 collaboration

Alejandro Martín-Quirós 1 collaboration

Charbel Maroun-Eid 1 collaboration

Juan José González-López 1 collaboration

Anna Fàbrega 1 collaboration

Verónica Terrón-Arcos 1 collaboration

María Gutiérrez-Fernández 1 collaboration

Elisa Alonso-López 1 collaboration

Carolina Cubillos-Zapata 1 collaboration

María Fernández-Velasco 1 collaboration

Rebeca Pérez de Diego 1 collaboration

Francisco J Cueto 1 collaboration

Carlos Del Fresno 1 collaboration

Eduardo López-Collazo 1 collaboration

Juan José Martínez-García 1 collaboration

Joaquín Amores-Iniesta 1 collaboration

Giovanni A Ercole 1 collaboration

Ada González-Lisorge 1 collaboration

José Fernández-Pacheco 1 collaboration

Piedad Martínez-Gil 1 collaboration

Friedrich Koch-Nolte 1 collaboration

Juan Luján 1 collaboration

Francisco Acosta-Villegas 1 collaboration

Pascual Parrilla 1 collaboration

Carolina Pellegrini 1 collaboration

Matteo Fornai 1 collaboration

Laura Benvenuti 1 collaboration

Rocchina Colucci 1 collaboration

Valentina Caputi 1 collaboration

Pablo Palazon-Riquelme 1 collaboration

Maria Cecilia Giron 1 collaboration

Anna Nericcio 1 collaboration

Francesca Garelli 1 collaboration

Vanessa D'Antongiovanni 1 collaboration

Cristina Segnani 1 collaboration

Chiara Ippolito 1 collaboration

Monica Nannipieri 1 collaboration

Gloria Lopez-Castejon 1 collaboration

György Haskó 1 collaboration

Nunzia Bernardini 1 collaboration

Corrado Blandizzi 1 collaboration

Luca Antonioli 1 collaboration

Julio García-Villalba 1 collaboration

Cristina Molina-Lopez 1 collaboration

Jalal Soubhye 1 collaboration

Michel Gelbcke 1 collaboration

Silvia Rodriguez-Lopez 1 collaboration

Kate Schroder 1 collaboration

Agustin Pappolla 1 collaboration

Luisa M M Villar 1 collaboration

Jordi Río 1 collaboration

Carlos J García 1 collaboration

Fernando Vallejo 1 collaboration

Joana R Marques-Soares 1 collaboration

Carmen Vargas 1 collaboration

Segundo Bujan-Rivas 1 collaboration

Francisco A Tomás-Barberán 1 collaboration

Carme Costa 1 collaboration

Herena Eixarch 1 collaboration

Christian W Keller 1 collaboration

Lukas Amman 1 collaboration

Luciana Midaglia 1 collaboration

Eduard Sarró 1 collaboration

Isabel Machín-Díaz 1 collaboration

Luisa M Villar 1 collaboration

Juan Carlos Triviño 1 collaboration

Begoña Oliver-Martos 1 collaboration

Laura Navarro Parladé 1 collaboration

Laura Calvo-Barreiro 1 collaboration

Fuencisla Matesanz 1 collaboration

Koen Vandenbroeck 1 collaboration

Elena Urcelay 1 collaboration

María-Luisa Martínez-Ginés 1 collaboration

Amalia Tejeda-Velarde 1 collaboration

Nicolás Fissolo 1 collaboration

Joaquín Castilló 1 collaboration

Alex Sanchez 1 collaboration

Avril A B Robertson 1 collaboration

Diego Clemente 1 collaboration

Marco Prinz 1 collaboration

Jan D Lünemann 1 collaboration

Carmen Espejo 1 collaboration

Liudmila Andreeva 1 collaboration

Liron David 1 collaboration

Shaun Rawson 1 collaboration

Chen Shen 1 collaboration

Teerithveen Pasricha 1 collaboration

Hao Wu 1 collaboration

Aleksandra Leszczynska 1 collaboration

Fernando Alegre 1 collaboration

Benedikt Kaufmann 1 collaboration

Casey D Johnson 1 collaboration

Leon A Adams 1 collaboration

Alexander Wree 1 collaboration

Georg Damm 1 collaboration

Daniel Seehofer 1 collaboration

Carolina J Calvente 1 collaboration

Davide Povero 1 collaboration

Tatiana Kisseleva 1 collaboration

Akiko Eguchi 1 collaboration

Matthew D McGeough 1 collaboration

Hal M Hoffman 1 collaboration

Ariel E Feldstein 1 collaboration

Juan J Martínez-García 1 collaboration

Javier Gil-Lianes 1 collaboration

Giuseppe Gariup 1 collaboration

Pilar Iranzo-Fernández 1 collaboration

Anna Mensa-Vilaró 1 collaboration

Juan I Aróstegui 1 collaboration

Vincent Compan 1 collaboration

Ana I Gómez 1 collaboration

María C Baños-Gregori 1 collaboration

Florian I Schmidt 1 collaboration

Jose Antonio García-Vidal 1 collaboration

Pilar Escolar-Reina 1 collaboration

Francesc Medina-Mirapeix 1 collaboration