Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome.
25-hydroxycholesterol
Cardiolipin
Caspase
Ceramide
Cholesterol
Inflammasome
Inflammation
Interleukin-1
Linoleic acid
Lipophosphoglycan
Lipopolysaccharide
Non-canonical inflammasome
Oleic acid
Ornithine lipid
Phosphatidylcholine
Phosphatidylinositol-4-phosphate
Polyunsaturated fatty acid
Pyroptosis
Saturated fatty acid
Sphingosine
Journal
Progress in lipid research
ISSN: 1873-2194
Titre abrégé: Prog Lipid Res
Pays: England
ID NLM: 7900832
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
04
02
2022
revised:
25
06
2022
accepted:
24
07
2022
pubmed:
29
7
2022
medline:
30
8
2022
entrez:
28
7
2022
Statut:
ppublish
Résumé
The inflammatory response is a complex regulated effector mechanism of the innate immune system that is initiated after tissue injury or infection. The NLRP3 inflammasome is an important initiator of inflammation by regulating the activation of caspase-1, the maturation of pro-inflammatory cytokines and the induction of pyroptotic cell death. Numerous studies demonstrate that the NLRP3 inflammasome could be modulated by lipids, existing a relation between lipids and the activation of different inflammatory processes. In this review we will summarize how the mechanism of NLRP3 inflammasome activation is regulated by different lipids and how these lipids control specific cellular localization of NLRP3 during activation. Although being a cytosolic protein, NLRP3 interacts with lipids accessible in neighbor membranes. Also, the modulation of NLRP3 by endogenous lipids has been found causative of different metabolic diseases and bacterial-pathogenic lipids lead to NLRP3 activation during infection. The understanding of the modulation of the NLRP3 inflammasome by lipids has resulted not only in a better knowledge about the mechanism of NLRP3 activation and its implication in disease, but also opens a new avenue for the development of novel therapeutics and vaccines, as NLRP3 could be modulated by synthetic lipids used as adjuvants.
Identifiants
pubmed: 35901922
pii: S0163-7827(22)00037-6
doi: 10.1016/j.plipres.2022.101182
pmc: PMC7613582
mid: EMS153712
pii:
doi:
Substances chimiques
Inflammasomes
0
Lipids
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101182Subventions
Organisme : European Research Council
ID : 899636
Pays : International
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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