Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.

Diffusion Magnetic Resonance Imaging Humans Ischemic Stroke Migraine with Aura / diagnostic imaging Migraine without Aura / diagnostic imaging Risk Factors
Common genetic variants MRI phenotype Migraine Posterior circulation ischemic stroke

Journal

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633

Informations de publication

Date de publication:
Aug 2022
Historique:
received: 15 03 2022
accepted: 01 05 2022
pubmed: 17 5 2022
medline: 27 7 2022
entrez: 16 5 2022
Statut: ppublish

Résumé

To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects. Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Exclusion criteria were lesions in both vascular territories or uncertain territory; supratentorial PCiS with ipsilateral fetal posterior cerebral artery; and cases with atrial fibrillation. We generated migraine PRS for three migraine phenotypes (any migraine; migraine without aura; migraine with aura) using publicly available GWAS data and compared mean PRSs separately for PCiS and ACiS vs. non-stroke control subjects, and between each stroke phenotype. Our primary analyses included 464 PCiS and 1079 ACiS patients with genetic European ancestry. Compared to non-stroke control subjects (n=15396), PRSs of any migraine were associated with increased risk of PCiS (p=0.01-0.03) and decreased risk of ACiS (p=0.010-0.039). Migraine without aura PRSs were significantly associated with PCiS (p=0.008-0.028), but not with ACiS. When comparing PCiS vs. ACiS directly, migraine PRSs were higher in PCiS vs. ACiS for any migraine (p=0.001-0.010) and migraine without aura (p=0.032-0.048). Migraine with aura PRS did not show a differential association in our analyses. Our results suggest a stronger genetic overlap between unspecified migraine and migraine without aura with PCiS compared to ACiS. Possible shared mechanisms include dysregulation of cerebral vessel endothelial function.

Identifiants

DOI: 10.1016/j.jstrokecerebrovasdis.2022.106546 PMID: 35576861 PMC: PMC10601407
pubmed: 35576861
pii: S1052-3057(22)00240-3
doi: 10.1016/j.jstrokecerebrovasdis.2022.106546
pmc: PMC10601407
mid: NIHMS1938618
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106546

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS082285
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS080168
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS069208
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS115388
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114045
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105150
Pays : United States
Organisme : BLRD VA
ID : I01 BX004672
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015902
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100178
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS086905
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

P Frid (P)

Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden; Section of Neurology, Skåne University Hospital, Malmö, Sweden. Electronic address: petrea.frid@med.lu.se.

H Xu (H)

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: hxu@som.umaryland.edu.

B D Mitchell (BD)

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD, USA.

M Drake (M)

Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden; Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden.

J Wasselius (J)

Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden; Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden.

B Gaynor (B)

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

K Ryan (K)

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

A K Giese (AK)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

M Schirmer (M)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

K L Donahue (KL)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

R Irie (R)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

M J R J Bouts (MJRJ)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

E C McIntosh (EC)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

S J T Mocking (SJT)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

A V Dalca (AV)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, USA.

E Giralt-Steinhauer (E)

Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain.

L Holmegaard (L)

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

K Jood (K)

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

J Roquer (J)

Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain.

J W Cole (JW)

Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.

P F McArdle (PF)

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

J P Broderick (JP)

Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

J Jimenez-Conde (J)

Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain.

C Jern (C)

Department of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.

B M Kissela (BM)

Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

D O Kleindorfer (DO)

Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

R Lemmens (R)

Department of Neurosciences, Experimental Neurology, VIB Center for Brain & Disease Research, Department of Neurology, University Hospitals Leuven, KU Leuven - University of Leuven, Leuven, Belgium.

J F Meschia (JF)

Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.

J Rosand (J)

Henry and Allison McCance Center for Brain Health Massachusetts General Hospital, Boston, USA.

T Rundek (T)

Department of Neurology, Miller School of Medicine, University of Miami, The Evelyn F. McKnight Brain Institute, FL, USA.

R L Sacco (RL)

Department of Neurology, Miller School of Medicine, University of Miami, The Evelyn F. McKnight Brain Institute, FL, USA.

R Schmidt (R)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Austria.

P Sharma (P)

Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, United Kingdom.

A Slowik (A)

Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.

V Thijs (V)

Stroke Division, Florey Institute of Neuroscience and Mental Health, and Department of Neurology, Austin Health, Heidelberg, Australia.

D Woo (D)

Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

B B Worrall (BB)

Departments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

S J Kittner (SJ)

Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.

J Petersson (J)

Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.

P Golland (P)

Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, USA.

O Wu (O)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

N S Rost (NS)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

A Lindgren (A)

Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden; Section of Neurology, Skåne University Hospital, Lund, Sweden.

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique de diffusion › Migraine-Associated Common Genetic Variants...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Migraine-Associated Common Genetic Variants...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Migraine-Associated Common Genetic Variants...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Migraine avec aura › Migraine-Associated Common Genetic Variants...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Migraine sans aura › Migraine-Associated Common Genetic Variants...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Migraine-Associated Common Genetic Variants...