Benzodiazepine Derivatives as Potent Vasopressin V

Animals Antidiuretic Hormone Receptor Antagonists / pharmacology Benzodiazepines / metabolism Cyclic AMP / metabolism Cysts / metabolism Humans Kidney / metabolism Mice Polycystic Kidney, Autosomal Dominant / drug therapy Receptors, Vasopressin / metabolism Vasopressins / metabolism

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 07 2022
Historique:
pubmed: 18 5 2022
medline: 16 7 2022
entrez: 17 5 2022
Statut: ppublish

Résumé

Cyst formation and enlargement in autosomal dominant kidney disease (ADPKD) is mainly driven by aberrantly increased cytosolic cAMP in renal tubule epithelial cells. Because the vasopressin V

Identifiants

DOI: 10.1021/acs.jmedchem.2c00567 PMID: 35579344
pubmed: 35579344
doi: 10.1021/acs.jmedchem.2c00567
doi:

Substances chimiques

Antidiuretic Hormone Receptor Antagonists 0
Receptors, Vasopressin 0
Vasopressins 11000-17-2
Benzodiazepines 12794-10-4
Cyclic AMP E0399OZS9N

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9295-9311

Auteurs

Xudong Cao (X)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Peng Wang (P)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Haoxing Yuan (H)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Haoran Zhang (H)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Yan He (Y)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Kequan Fu (K)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Qian Fang (Q)

The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221002, China.

Hongli Liu (H)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Limin Su (L)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Long Yin (L)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Pei Xu (P)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Yuyang Xie (Y)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Xiaochun Xiong (X)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Junqi Wang (J)

The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221002, China.

Xu Zhu (X)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.

Dong Guo (D)

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China.
ORCID: 0000-0001-6142-4825

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Antagonistes des récepteurs de l'hormone antidiurétique › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP cyclique › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Kystes › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Ciliopathies › Polykystoses rénales › Polykystose rénale autosomique dominante › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteurs à la vasopressine › Benzodiazepine Derivatives as Potent Vasopressin V
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Vasopressines › Benzodiazepine Derivatives as Potent Vasopressin V