Protein interaction network analysis reveals genetic enrichment of immune system genes in frontotemporal dementia.

Cohort Studies Frontotemporal Dementia / metabolism Humans Immune System Protein Interaction Maps Tumor Necrosis Factor alpha-Induced Protein 3 / metabolism
Candidate gene prioritization Frontotemporal dementia Protein-protein interaction network Rare variant association analysis

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
08 2022
Historique:
received: 03 01 2022
revised: 09 03 2022
accepted: 31 03 2022
pubmed: 18 5 2022
medline: 9 6 2022
entrez: 17 5 2022
Statut: ppublish

Résumé

Interactors of protein products of known genes for frontotemporal dementia (FTD) are likely to be involved in the molecular pathways towards disease. We therefore applied protein interaction network (PIN) analysis to prioritize candidate genes for rare variant association analysis. We created an FTD-PIN starting from known FTD genes downloading their physical interactors and performed functional enrichment analyses. We identified overrepresented processes in FTD and selected genes (n = 440) belonging to these processes for rare variant analysis in a Belgian cohort of 228 FTD patients and 345 controls. SKAT-O analysis suggested TNFAIP3 as the top gene (p = 0.7 × 10

Identifiants

DOI: 10.1016/j.neurobiolaging.2022.03.018 PMID: 35580510
pubmed: 35580510
pii: S0197-4580(22)00069-0
doi: 10.1016/j.neurobiolaging.2022.03.018
pii:
doi:

Substances chimiques

TNFAIP3 protein, human EC 3.4.19.12
Tumor Necrosis Factor alpha-Induced Protein 3 EC 3.4.19.12

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

67-79

Informations de copyright

Copyright © 2022. Published by Elsevier Inc.

Auteurs

Cemile Koçoğlu (C)

Neurodegenerative Brain Diseases, VIB Center for Molecular Neurology, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

Raffaele Ferrari (R)

Department of Neurodegenerative Disease, London, UK.

Maxime Roes (M)

Neurodegenerative Brain Diseases, VIB Center for Molecular Neurology, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

Geert Vandeweyer (G)

Department of Medical Genetics, University of Antwerp, Antwerp, Belgium.

R Frank Kooy (RF)

Department of Medical Genetics, University of Antwerp, Antwerp, Belgium.

Christine Van Broeckhoven (C)

Neurodegenerative Brain Diseases, VIB Center for Molecular Neurology, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

Claudia Manzoni (C)

School of Pharmacy, London, UK. Electronic address: c.manzoni@ucl.ac.uk.

Julie van der Zee (J)

Neurodegenerative Brain Diseases, VIB Center for Molecular Neurology, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: julie.vanderzee@uantwerpen.vib.be.

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Classifications MeSH

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