A History of Cancer Research: Retroviral Oncogenes.
Journal
Cold Spring Harbor perspectives in medicine
ISSN: 2157-1422
Titre abrégé: Cold Spring Harb Perspect Med
Pays: United States
ID NLM: 101571139
Informations de publication
Date de publication:
17 05 2022
17 05 2022
Historique:
pmc-release:
01
04
2024
entrez:
17
5
2022
pubmed:
18
5
2022
medline:
20
5
2022
Statut:
epublish
Résumé
The discovery and characterization of retroviral oncogenes were important milestones in cancer research. The viruses turned out not to be key causes of cancer in humans, but the oncogenes they carried provided key clues to the role cellular genes, the proto-oncogene counterparts of these sequences, played in tumorigenesis. In this excerpt from his forthcoming book, Joe Lipsick looks back at early work on retroviruses, such as the experiments that distinguished their ability to infect and transform cells, the groundbreaking work on Src, and some of the controversy surrounding the Nobel Prize awarded for these discoveries.
Identifiants
pubmed: 35581009
pii: 12/4/a035865
doi: 10.1101/cshperspect.a035865
pmc: PMC9121892
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2022 Joseph Lipsick; published by Cold Spring Harbor Laboratory Press; all rights reserved.