Cytoplasmic gene expression: lessons from poxviruses.

Cell Nucleus / genetics Cytoplasm / genetics DNA-Directed RNA Polymerases / chemistry Gene Expression Poxviridae / genetics RNA Polymerase II / genetics Transcription, Genetic
RNA polymerase cryo EM poxviruses structural biology transcription vaccinia

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
10 2022
Historique:
received: 18 01 2022
revised: 12 04 2022
accepted: 20 04 2022
pubmed: 18 5 2022
medline: 14 9 2022
entrez: 17 5 2022
Statut: ppublish

Résumé

In eukaryotic cells, the process of gene expression is confined to the nucleus and enabled by multisubunit RNA polymerases (RNAPs). Many viruses make use of the host cellular gene expression apparatus during infection, and hence transfer their genome at least transiently to the host nucleus. However, poxviruses have evolved a different strategy to propagate. Their double-stranded DNA genome is transcribed in the host cytoplasm by a virus-encoded RNAP (vRNAP), which is evolutionarily related to eukaryotic RNA polymerase II. In this Review, we highlight recent high-resolution structures of the poxviral transcription apparatus in different phases of action. These structures, along with biochemical data, now allow the definition of a comprehensive model of poxviral gene expression and its regulation.

Identifiants

DOI: 10.1016/j.tibs.2022.04.010 PMID: 35581053
pubmed: 35581053
pii: S0968-0004(22)00095-0
doi: 10.1016/j.tibs.2022.04.010
pii:
doi:

Substances chimiques

RNA Polymerase II EC 2.7.7.-
DNA-Directed RNA Polymerases EC 2.7.7.6

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

892-902

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Clemens Grimm (C)

Department of Biochemistry and Cancer Therapy Research Center (CTRC), Theodor Boveri-Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. Electronic address: Clemens.grimm@biozentrum.uni-wuerzburg.de.

Julia Bartuli (J)

Department of Biochemistry and Cancer Therapy Research Center (CTRC), Theodor Boveri-Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.

Utz Fischer (U)

Department of Biochemistry and Cancer Therapy Research Center (CTRC), Theodor Boveri-Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Wuerzburg, Germany. Electronic address: utz.fischer@biozentrum.uni-wuerzburg.de.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Cytoplasmic gene expression: lessons from poxviruses.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Cytoplasmic gene expression: lessons from poxviruses.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › Cytoplasmic gene expression: lessons from poxviruses.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Cytoplasmic gene expression: lessons from poxviruses.
questionsmedicales.fr › Virus › Virus à ADN › Poxviridae › Cytoplasmic gene expression: lessons from poxviruses.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › Cytoplasmic gene expression: lessons from poxviruses.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Cytoplasmic gene expression: lessons from poxviruses.