Targeting DEAD-box RNA helicases: The emergence of molecular staples.
DDX proteins
RNA helicase
chemical biology
helicase inhibitors
molecular staples
Journal
Wiley interdisciplinary reviews. RNA
ISSN: 1757-7012
Titre abrégé: Wiley Interdiscip Rev RNA
Pays: United States
ID NLM: 101536955
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
13
04
2022
received:
15
02
2022
accepted:
16
04
2022
pubmed:
19
5
2022
medline:
15
3
2023
entrez:
18
5
2022
Statut:
ppublish
Résumé
RNA helicases constitute a large family of proteins that play critical roles in mediating RNA function. They have been implicated in all facets of gene expression pathways involving RNA, from transcription to processing, transport and translation, and storage and decay. There is significant interest in developing small molecule inhibitors to RNA helicases as some family members have been documented to be dysregulated in neurological and neurodevelopment disorders, as well as in cancers. Although different functional properties of RNA helicases offer multiple opportunities for small molecule development, molecular staples have recently come to the forefront. These bifunctional molecules interact with both protein and RNA components to lock them together, thereby imparting novel gain-of-function properties to their targets. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule-RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.
Substances chimiques
RNA
63231-63-0
DEAD-box RNA Helicases
EC 3.6.4.13
RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1738Subventions
Organisme : CIHR
ID : FDN-148366
Pays : Canada
Informations de copyright
© 2022 Wiley Periodicals LLC.
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