Vaccinia Virus Attenuation by Codon Deoptimization of the A24R Gene for Vaccine Development.


Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
29 06 2022
Historique:
pubmed: 19 5 2022
medline: 2 7 2022
entrez: 18 5 2022
Statut: ppublish

Résumé

Poxviruses have large DNA genomes, and they are able to infect multiple vertebrate and invertebrate animals, including humans. Despite the eradication of smallpox, poxvirus infections still remain a significant public health concern. Vaccinia virus (VV) is the prototypic member in the

Identifiants

pubmed: 35583360
doi: 10.1128/spectrum.00272-22
pmc: PMC9241885
doi:

Substances chimiques

Codon 0
Vaccines, Attenuated 0
Viral Replicase Complex Proteins 0
Viral Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0027222

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Auteurs

María M Lorenzo (MM)

Departamento de Biotecnología, Centro Nacional INIA, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

Aitor Nogales (A)

Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Animal Health Research Centre (CISA), National Institute for Agriculture and Food Research and Technology (INIA-CSIC), Valdeolmos, Madrid, Spain.

Kevin Chiem (K)

Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Texas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.

Rafael Blasco (R)

Departamento de Biotecnología, Centro Nacional INIA, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

Luis Martínez-Sobrido (L)

Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Texas Biomedical Research Institutegrid.250889.e, San Antonio, Texas, USA.

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Classifications MeSH