Adrenal crises in adolescents and young adults.
Adrenal insufficiency
Emergening adults
Incidence
Mortality
Precipitating factors
Prevention
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
12
04
2022
accepted:
03
05
2022
pubmed:
19
5
2022
medline:
2
7
2022
entrez:
18
5
2022
Statut:
ppublish
Résumé
Review the literature concerning adrenal insufficiency (AI) and adrenal crisis (AC) in adolescents and young adults. Searches of PubMed identifying relevant reports up to March 2022. AI is rare disorder that requires lifelong glucocorticoid replacement therapy and is associated with substantial morbidity and occasional mortality among adolescents and young adults. Aetiologies in this age group are more commonly congenital, with acquired causes, resulting from tumours in the hypothalamic-pituitary area and autoimmune adrenalitis among others, increasing with age. All patients with AI are at risk of AC, which have an estimated incidence of 6 to 8 ACs/100 patient years. Prevention of ACs includes use of educational interventions to achieve competency in dose escalation and parenteral glucocorticoid administration during times of physiological stress, such as an intercurrent infection. While the incidence of AI/AC in young children and adults has been documented, there are few studies focussed on the AC occurrence in adolescents and young adults with AI. This is despite the range of developmental, psychosocial, and structural changes that can interfere with chronic disease management during this important period of growth and development. In this review, we examine the current state of knowledge of AC epidemiology in emerging adults; examine the causes of ACs in this age group; and suggest areas for further investigation that are aimed at reducing the incidence and health impact of ACs in these patients.
Identifiants
pubmed: 35583847
doi: 10.1007/s12020-022-03070-3
pii: 10.1007/s12020-022-03070-3
pmc: PMC9242908
doi:
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Informations de copyright
© 2022. The Author(s).
Références
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