ROS1-positive Inflammatory Myofibroblastic Tumor of the Small Bowel Causing Obstruction: A Case Report.
Bowel solitary mast cell tumor
Inflammatory Myofibroblastic Tumor
Inflammatory pseudotumor
Small bowel obstruction
extra-pulmonary Inflammatory Myofibroblastic Tumors
Journal
Journal of radiology case reports
ISSN: 1943-0922
Titre abrégé: J Radiol Case Rep
Pays: United States
ID NLM: 101494925
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
entrez:
19
5
2022
pubmed:
20
5
2022
medline:
21
5
2022
Statut:
epublish
Résumé
Inflammatory Myofibroblastic Tumors (IMTs) are rare fibroblastic/myofibroblastic neoplasms that affect predominately pediatric patients and young adults. Almost half of the patients with IMTs have a chromosomal abnormality in the Anaplastic Lymphoma Kinase 1 gene on chromosome 2p23. Although these tumors occur primarily in the lung, lesions have been reported in a variety of intra-abdominal organs like the liver, spleen, and mesentery. Small bowel IMTs are particularly rare. IMTs generally pursue a benign clinical course, however intra-abdominal and retroperitoneal tumors have typically shown higher local recurrence and even distant metastases. The most common presenting symptoms of an intra-abdominal IMT are abdominal pain and change in bowel habits. Laboratory results are nonspecific and can include anemia and minor elevation of inflammatory markers like C-reactive protein. We report an unusual case of IMT in the small bowel causing the obstruction.
Identifiants
pubmed: 35586084
doi: 10.3941/jrcr.v16i1.3928
pii: jrcr-16-1-14
pmc: PMC9063829
doi:
Substances chimiques
Proto-Oncogene Proteins
0
Protein-Tyrosine Kinases
EC 2.7.10.1
ROS1 protein, human
EC 2.7.10.1
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
14-21Informations de copyright
Copyright Journal of Radiology Case Reports.
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