Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.


Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
17 06 2022
Historique:
pubmed: 20 5 2022
medline: 22 6 2022
entrez: 19 5 2022
Statut: ppublish

Résumé

The molecular basis of interindividual clinical variability upon infection with

Identifiants

pubmed: 35587511
doi: 10.1126/science.abm6380
pmc: PMC9233084
mid: NIHMS1809523
doi:

Substances chimiques

Bacterial Toxins 0
Hemolysin Proteins 0
staphylococcal alpha-toxin 0
Endopeptidases EC 3.4.-
OTULIN protein, human EC 3.4.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabm6380

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI127372
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148963
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140754
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105129
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI061093
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121244
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137336
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI099394
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States

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Auteurs

András N Spaan (AN)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Anna-Lena Neehus (AL)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.
Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany.

Emmanuel Laplantine (E)

Centre d'Immunologie et des Maladies Infectieuses, INSERM U1135, CNRS ERL8255, Sorbonne University, 75724 Paris, France.
Institut de Recherche St. Louis, Hôpital St. Louis, INSERM U944, CNRS U7212, Paris Cité University, 75010 Paris, France.

Frederik Staels (F)

Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.

Masato Ogishi (M)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.

Yoann Seeleuthner (Y)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.

Franck Rapaport (F)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.

Keenan A Lacey (KA)

Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.

Erika Van Nieuwenhove (E)

Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Department of Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Maya Chrabieh (M)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.

David Hum (D)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.

Mélanie Migaud (M)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.

Araksya Izmiryan (A)

Imagine Institute, Paris Cité University, 75015 Paris, France.
Laboratory of Genetic Skin Diseases, INSERM U1163, 75015 Paris, France.

Lazaro Lorenzo (L)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.

Tatiana Kochetkov (T)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.

Dani A C Heesterbeek (DAC)

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Bart W Bardoel (BW)

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Ashley L DuMont (AL)

Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.

Kerry Dobbs (K)

Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20852, USA.

Solenne Chardonnet (S)

Plateforme Post-génomique de la Pitié-Salpêtrière, P3S, UMS Production et Analyse de données en Sciences de la vie et en Santé, PASS, INSERM, Sorbonne University, 75013 Paris, France.

Søren Heissel (S)

Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.

Timour Baslan (T)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Peng Zhang (P)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.

Rui Yang (R)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.

Dusan Bogunovic (D)

Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Herman F Wunderink (HF)

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Pieter-Jan A Haas (PA)

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Henrik Molina (H)

Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.

Griet Van Buggenhout (G)

Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
Center for Human Genetics, University Hospitals Leuven, 3000 Leuven, Belgium.

Stanislas Lyonnet (S)

Imagine Institute, Paris Cité University, 75015 Paris, France.
Laboratory Embryology and Genetics of Malformations, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.

Luigi D Notarangelo (LD)

Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20852, USA.

Mikko R J Seppänen (MRJ)

Rare Disease and Pediatric Research Centers, Children and Adolescents, University of Helsinki and HUS Helsinki University Hospital, 00260 Helsinki, Finland.

Robert Weil (R)

Centre d'Immunologie et des Maladies Infectieuses, INSERM U1135, CNRS ERL8255, Sorbonne University, 75724 Paris, France.

Gisela Seminario (G)

Center for Clinical Immunology, Immunology Group Children's Hospital Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina.

Héctor Gomez-Tello (H)

Immunology Department, Poblano Children's Hospital, 72190 Puebla, Mexico.

Carine Wouters (C)

Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Department of Pediatrics, University Hospitals Leuven, 3000 Leuven, Belgium.

Mehrnaz Mesdaghi (M)

Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, 15468-155514 Tehran, Iran.

Mohammad Shahrooei (M)

Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, 15468-155514 Ahvaz, Iran.

Xavier Bossuyt (X)

Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.

Erdal Sag (E)

Department of Pediatric Rheumatology, Hacettepe University, 06230 Ankara, Turkey.

Rezan Topaloglu (R)

Department of Pediatric Nephrology, Hacettepe University School of Medicine, Hacettepe University, 06230 Ankara, Turkey.

Seza Ozen (S)

Department of Pediatric Rheumatology, Hacettepe University, 06230 Ankara, Turkey.

Helen L Leavis (HL)

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Maarten M J van Eijk (MMJ)

Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

Liliana Bezrodnik (L)

Center for Clinical Immunology, Immunology Group Children's Hospital Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina.

Lizbeth Blancas Galicia (L)

Immune Deficiencies Laboratory National Institute of Pediatrics, 04530 Mexico City, Mexico.

Alain Hovnanian (A)

Imagine Institute, Paris Cité University, 75015 Paris, France.
Laboratory of Genetic Skin Diseases, INSERM U1163, 75015 Paris, France.
Department of Genetics, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.

Aude Nassif (A)

Centre Médical, Institut Pasteur, 75724 Paris, France.

Brigitte Bader-Meunier (B)

Imagine Institute, Paris Cité University, 75015 Paris, France.
Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.

Bénédicte Neven (B)

Imagine Institute, Paris Cité University, 75015 Paris, France.
Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.

Isabelle Meyts (I)

Laboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, 3000 Leuven, Belgium.

Rik Schrijvers (R)

Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.

Anne Puel (A)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.

Jacinta Bustamante (J)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.
Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.

Ivona Aksentijevich (I)

Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD 20892, USA.

Daniel L Kastner (DL)

Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD 20892, USA.

Victor J Torres (VJ)

Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.

Stéphanie Humblet-Baron (S)

Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.

Adrian Liston (A)

Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
VIB Center for Brain and Disease Research, Leuven 3000, Belgium.
Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

Laurent Abel (L)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.

Bertrand Boisson (B)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.

Jean-Laurent Casanova (JL)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Imagine Institute, Paris Cité University, 75015 Paris, France.
Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

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