Malnutrition, hemodynamics and inflammation in heart failure with reduced, mildly reduced and preserved ejection fraction.
HFmrEF
HFpEF
Inflammation
Malnutrition
Prognosis
Journal
Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
27
10
2021
accepted:
27
04
2022
pubmed:
20
5
2022
medline:
30
9
2022
entrez:
19
5
2022
Statut:
ppublish
Résumé
In patients with heart failure (HF) with reduced ejection fraction (HFrEF), malnutrition can be associated with intestinal congestion and systemic inflammation. These relationships have not been fully investigated in HF with mildly reduced EF (HFmrEF) and with preserved EF (HFpEF). We analyzed 420 patients with HF who underwent right heart catheterization. The relationships between hemodynamic parameters, C-reactive protein, and the controlling nutritional (CONUT) score were investigated in HFrEF, HFmrEF and HFpEF. The CONUT score of all patients was 2 [1, 4] (median [interquartile range]), and was not significantly different between the left ventricular EF (LVEF) categories (2 [1, 3] for HFrEF, 2 [1, 3] for HFmrEF, and 3 [1, 4] for HFpEF, p = 0.279). In multivariate linear regression analyses, there was a significant association between CRP and the CONUT score in HFmrEF and HFpEF, while brain natriuretic peptide and right atrial pressure were significantly associated with the CONUT score in HFrEF. Higher CONUT scores predicted a higher incidence of the composite endpoint of death or HF hospitalization within 12 months without an interaction with LVEF (p = 0.980). The CONUT score was an independent predictor of the composite endpoint, death, and HF hospitalization after adjustment for confounders in the multivariate analysis. In conclusion, inflammation was associated with malnutrition in HFmrEF and HFpEF, while congestion was an independent predictor of malnutrition in HFrEF. Malnutrition predicted worse outcomes regardless of LVEF.
Identifiants
pubmed: 35588322
doi: 10.1007/s00380-022-02090-3
pii: 10.1007/s00380-022-02090-3
doi:
Substances chimiques
Natriuretic Peptide, Brain
114471-18-0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1841-1849Informations de copyright
© 2022. Springer Japan KK, part of Springer Nature.
Références
Anker SD, Negassa A, Coats AJ, Afzal R, Poole-Wilson PA, Cohn JN, Yusuf S (2003) Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study. Lancet 361(9363):1077–1083
doi: 10.1016/S0140-6736(03)12892-9
Horiuchi Y, Tanimoto S, Okuno T, Aoki J, Yahagi K, Sato Y, Tanaka T, Koseki K, Komiyama K, Nakajima H, Hara K, Tanabe K (2018) Hemodynamic correlates of nutritional indexes in heart failure. J Cardiol 71(6):557–563
doi: 10.1016/j.jjcc.2017.11.006
Santos NFD, Pinho CPS, Cardoso A, Mendes RML (2018) Cachexia in hospitalized patients with heart failure. Nutr Hosp 35(3):669–676
pubmed: 29974778
Valentova M, Anker SD, von Haehling S (2020) Cardiac cachexia revisited: the role of wasting in heart failure. Heart Fail Clin 16(1):61–69
doi: 10.1016/j.hfc.2019.08.006
Carr JG, Stevenson LW, Walden JA, Heber D (1989) Prevalence and hemodynamic correlates of malnutrition in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 63(11):709–713
doi: 10.1016/0002-9149(89)90256-7
Krack A, Sharma R, Figulla HR, Anker SD (2005) The importance of the gastrointestinal system in the pathogenesis of heart failure. Eur Heart J 26(22):2368–2374
doi: 10.1093/eurheartj/ehi389
Pasini E, Aquilani R, Testa C, Baiardi P, Angioletti S, Boschi F, Verri M, Dioguardi F (2016) Pathogenic gut flora in patients with chronic heart failure. JACC Heart Fail 4(3):220–227
doi: 10.1016/j.jchf.2015.10.009
Horwich TB, Kalantar-Zadeh K, MacLellan RW, Fonarow GC (2008) Albumin levels predict survival in patients with systolic heart failure. Am Heart J 155(5):883–889
doi: 10.1016/j.ahj.2007.11.043
Ignacio de Ulibarri J, Gonzalez-Madrono A, de Villar NG, Gonzalez P, Gonzalez B, Mancha A, Rodriguez F, Fernandez G (2005) CONUT: a tool for controlling nutritional status. First validation in a hospital population. Nutr Hosp 20(1):38–45
pubmed: 15762418
Ommen SR, Hodge DO, Rodeheffer RJ, McGregor CG, Thomson SP, Gibbons RJ (1998) Predictive power of the relative lymphocyte concentration in patients with advanced heart failure. Circulation 97(1):19–22
doi: 10.1161/01.CIR.97.1.19
Rauchhaus M, Clark AL, Doehner W, Davos C, Bolger A, Sharma R, Coats AJ, Anker SD (2003) The relationship between cholesterol and survival in patients with chronic heart failure. J Am Coll Cardiol 42(11):1933–1940
doi: 10.1016/j.jacc.2003.07.016
Ferrari R, Fucili A, Rapezzi C (2020) Understanding the results of the PARAGON-HF trial. Eur J Heart Fail 22(9):1531–1535
doi: 10.1002/ejhf.1797
Paulus WJ, Tschope C (2013) A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 62(4):263–271
doi: 10.1016/j.jacc.2013.02.092
Peterson PN, Rumsfeld JS, Liang L et al (2010) A validated risk score for in-hospital mortality in patients with heart failure from the American Heart Association get with the guidelines program. Circ Cardiovasc Qual Outcomes 3:25–32
doi: 10.1161/CIRCOUTCOMES.109.854877
Pocock SJ, Ariti CA, McMurray JJV et al (2013) Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies. Eur Heart J 34:1404–1413
doi: 10.1093/eurheartj/ehs337
Alibay Y, Schmitt C, Beauchet A, Dubourg O, Alexandre JA, Boileau C, Jondeau G, Puy H (2005) Non-radioimmunometric NT-ProBNP and BNP assays: impact of diluent, age, gender, BMI. Ann Biol Clin (Paris) 63(1):43–49
Chien SC, Lo CI, Lin CF, Sung KT, Tsai JP, Huang WH, Yun CH, Hung TC, Lin JL, Liu CY, Hou CJ, Tsai IH, Su CH, Yeh HI, Hung CL (2019) Malnutrition in acute heart failure with preserved ejection fraction: clinical correlates and prognostic implications. ESC Heart Fail 6(5):953–964
doi: 10.1002/ehf2.12501
Komorita T, Yamamoto E, Sueta D, Tokitsu T, Fujisue K, Usuku H, Nishihara T, Oike F, Takae M, Egashira K, Takashio S, Ito M, Yamanaga K, Arima Y, Sakamoto K, Suzuki S, Kaikita K, Tsujita K (2020) The controlling nutritional status score predicts outcomes of cardiovascular events in patients with heart failure with preserved ejection fraction. Int J Cardiol Heart Vasc 29:100563
pubmed: 32637567
pmcid: 7326720
Minamisawa M, Seidelmann SB, Claggett B, Hegde SM, Shah AM, Desai AS, Lewis EF, Shah SJ, Sweitzer NK, Fang JC, Anand IS, O’Meara E, Rouleau JL, Pitt B, Solomon SD (2019) Impact of malnutrition using geriatric nutritional risk index in heart failure with preserved ejection fraction. JACC Heart Fail 7(8):664–675
doi: 10.1016/j.jchf.2019.04.020
Glezeva N, Baugh JA (2014) Role of inflammation in the pathogenesis of heart failure with preserved ejection fraction and its potential as a therapeutic target. Heart Fail Rev 19(5):681–694
doi: 10.1007/s10741-013-9405-8
Anand IS, Latini R, Florea VG, Kuskowski MA, Rector T, Masson S, Signorini S, Mocarelli P, Hester A, Glazer R, Cohn JN, Val-He FTI (2005) C-reactive protein in heart failure: prognostic value and the effect of valsartan. Circulation 112(10):1428–1434
doi: 10.1161/CIRCULATIONAHA.104.508465
Iwanaga Y, Nishi I, Furuichi S, Noguchi T, Sase K, Kihara Y, Goto Y, Nonogi H (2006) B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: comparison between systolic and diastolic heart failure. J Am Coll Cardiol 47(4):742–748
doi: 10.1016/j.jacc.2005.11.030
Joaquin C, Alonso N, Lupon J, de Antonio M, Domingo M, Moliner P, Zamora E, Codina P, Ramos A, Gonzalez B, Rivas C, Cachero M, Puig-Domingo M, Bayes-Genis A (2020) Mini Nutritional Assessment Short Form is a morbi-mortality predictor in outpatients with heart failure and mid-range left ventricular ejection fraction. Clin Nutr 39(11):3395–3401
doi: 10.1016/j.clnu.2020.02.031
Agra Bermejo RM, Gonzalez Ferreiro R, Varela Roman A, Gomez Otero I, Kreidieh O, Conde Sabaris P, Rodriguez-Manero M, Moure Gonzalez M, Seoane Blanco A, Virgos Lamela A, Garcia Castelo A, Gonzalez Juanatey JR (2017) Nutritional status is related to heart failure severity and hospital readmissions in acute heart failure. Int J Cardiol 230:108–114
doi: 10.1016/j.ijcard.2016.12.067
Iwakami N, Nagai T, Furukawa TA, Sugano Y, Honda S, Okada A, Asaumi Y, Aiba T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T, Defi N (2017) Prognostic value of malnutrition assessed by controlling nutritional status score for long-term mortality in patients with acute heart failure. Int J Cardiol 230:529–536
doi: 10.1016/j.ijcard.2016.12.064
Kato T, Yaku H, Morimoto T, Inuzuka Y, Tamaki Y, Yamamoto E, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Su K, Kawato M, Seko Y, Inoko M, Toyofuku M, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Sato Y, Kuwahara K, Ozasa N, Kimura T (2020) Association with Controlling Nutritional Status (CONUT) score and in-hospital mortality and infection in acute heart failure. Sci Rep 10(1):3320
doi: 10.1038/s41598-020-60404-9
Narumi T, Arimoto T, Funayama A, Kadowaki S, Otaki Y, Nishiyama S, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Watanabe T, Kubota I (2013) Prognostic importance of objective nutritional indexes in patients with chronic heart failure. J Cardiol 62(5):307–313
doi: 10.1016/j.jjcc.2013.05.007
Nochioka K, Sakata Y, Takahashi J, Miyata S, Miura M, Takada T, Fukumoto Y, Shiba N, Shimokawa H, Investigators C (2013) Prognostic impact of nutritional status in asymptomatic patients with cardiac diseases: a report from the CHART-2 Study. Circ J 77(9):2318–2326
doi: 10.1253/circj.CJ-13-0127
Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Ecke A, Abou-El-Ardat K, Schmid T, Brune B, Wagner S, Serve H, Hoffmann J, Seeger F, Dimmeler S, Zeiher AM, Rieger MA (2019) Association of mutations contributing to clonal hematopoiesis with prognosis in chronic ischemic heart failure. JAMA Cardiol 4(1):25–33
doi: 10.1001/jamacardio.2018.3965
Lee MS, Duan L, Clare R, Hekimian A, Spencer H, Chen W (2018) Comparison of effects of statin use on mortality in patients with heart failure and preserved versus reduced left ventricular ejection fraction. Am J Cardiol 122(3):405–412
doi: 10.1016/j.amjcard.2018.04.027
Preiss D, Campbell RT, Murray HM, Ford I, Packard CJ, Sattar N, Rahimi K, Colhoun HM, Waters DD, LaRosa JC, Amarenco P, Pedersen TR, Tikkanen MJ, Koren MJ, Poulter NR, Sever PS, Ridker PM, MacFadyen JG, Solomon SD, Davis BR, Simpson LM, Nakamura H, Mizuno K, Marfisi RM, Marchioli R, Tognoni G, Athyros VG, Ray KK, Gotto AM, Clearfield MB, Downs JR, McMurray JJ (2015) The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. Eur Heart J 36(24):1536–1546
doi: 10.1093/eurheartj/ehv072