Higher Serum Soluble TREM2 as a Potential Indicative Biomarker for Cognitive Impairment in Inadequately Controlled Type 2 Diabetes Without Obesity: The DOR-KyotoJ-1.
cognitive impairment (CI)
glycemic control
longitudinal cohort study
serum soluble TREM2
type 2 diabetes
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
02
2022
accepted:
30
03
2022
entrez:
20
5
2022
pubmed:
21
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
Type 2 diabetes is a risk factor for dementia. We investigated whether serum levels of soluble triggering receptor expressed on myeloid cell 2 (sTREM2), a soluble form of the cell surface receptor TREM2, were predictive of cognitive impairment in type 2 diabetes without obesity. A total of 166 Japanese patients with type 2 diabetes without obesity were followed-up for 2 years. We measured clinical parameters, assessed cognitive function using the mini-mental state examination (MMSE), quantified and divided serum sTREM2 levels into quartiles, and examined the longitudinal associations. During the follow-up, HbA Glycemic control is suggested to be important in preventing cognitive impairment in patients with type 2 diabetes without obesity. Higher serum sTREM2 levels would be a predictive marker for cognitive impairment in inadequately controlled type 2 diabetes without obesity.
Identifiants
pubmed: 35592778
doi: 10.3389/fendo.2022.880148
pmc: PMC9110765
doi:
Substances chimiques
Biomarkers
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
TREM2 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
880148Informations de copyright
Copyright © 2022 Tanaka, Yamakage, Muranaka, Yamada, Araki, Ogo, Matoba, Watanabe, Saito, Kurita, Yonezawa, Tanaka, Suzuki, Sawamura, Matsumoto, Nishimura, Kusakabe, Wada, Hasegawa, Kotani, Noda and Satoh-Asahara.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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