SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening.
Antiviral screen
CPE
Glioblastoma
Omicron
SARS-CoV-2
U87 cell line
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
13
02
2022
revised:
12
04
2022
accepted:
11
05
2022
pubmed:
21
5
2022
medline:
11
6
2022
entrez:
20
5
2022
Statut:
ppublish
Résumé
Despite the great success of the administered vaccines against SARS-CoV-2, the virus can still spread, as evidenced by the current circulation of the highly contagious Omicron variant. This emphasizes the additional need to develop effective antiviral countermeasures. In the context of early preclinical studies for antiviral assessment, robust cellular infection systems are required to screen drug libraries. In this study, we reported the implementation of a human glioblastoma cell line, stably expressing ACE2, in a SARS-CoV-2 cytopathic effect (CPE) reduction assay. These glioblastoma cells, designated as U87.ACE2
Identifiants
pubmed: 35595082
pii: S0166-3542(22)00111-5
doi: 10.1016/j.antiviral.2022.105342
pmc: PMC9113983
pii:
doi:
Substances chimiques
Antiviral Agents
0
COVID-19 Vaccines
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105342Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
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