What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
31
12
2021
accepted:
26
04
2022
revised:
20
04
2022
pubmed:
21
5
2022
medline:
7
12
2022
entrez:
20
5
2022
Statut:
ppublish
Résumé
Substantial progress has been made in the understanding of anorexia nervosa (AN) and eating disorder (ED) genetics through the efforts of large-scale collaborative consortia, yielding the first genome-wide significant loci, AN-associated genes, and insights into metabo-psychiatric underpinnings of the disorders. However, the translatability, generalizability, and reach of these insights are hampered by an overly narrow focus in our research. In particular, stereotypes, myths, assumptions and misconceptions have resulted in incomplete or incorrect understandings of ED presentations and trajectories, and exclusion of certain patient groups from our studies. In this review, we aim to counteract these historical imbalances. Taking as our starting point the Academy for Eating Disorders (AED) Truth #5 "Eating disorders affect people of all genders, ages, races, ethnicities, body shapes and weights, sexual orientations, and socioeconomic statuses", we discuss what we do and do not know about the genetic underpinnings of EDs among people in each of these groups, and suggest strategies to design more inclusive studies. In the second half of our review, we outline broad strategic goals whereby ED researchers can expand the diversity, insights, and clinical translatability of their studies.
Identifiants
pubmed: 35595976
doi: 10.1038/s41380-022-01601-y
pii: 10.1038/s41380-022-01601-y
pmc: PMC9718676
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3929-3938Subventions
Organisme : NIMH NIH HHS
ID : R01 MH120170
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124839
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124871
Pays : United States
Informations de copyright
© 2022. The Author(s).
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