On the kinetic mechanism of dimethylarginine dimethylaminohydrolase.

Amidohydrolases / chemistry Arginine / pharmacology Humans Kinetics Nitric Oxide / chemistry Nitric Oxide Synthase / chemistry
Covalent intermediate Dimethylarginine Global fitting Methylarginine Rapid quench-flow

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
15 07 2022
Historique:
received: 24 03 2022
revised: 06 05 2022
accepted: 09 05 2022
pubmed: 23 5 2022
medline: 3 6 2022
entrez: 22 5 2022
Statut: ppublish

Résumé

Dimethylarginine dimethylaminohydrolase (DDAH, EC 3.5.3.18) catalyzes the hydrolysis of asymmetric N

Identifiants

DOI: 10.1016/j.bmc.2022.116816 PMID: 35598478
pubmed: 35598478
pii: S0968-0896(22)00208-5
doi: 10.1016/j.bmc.2022.116816
pii:
doi:

Substances chimiques

Nitric Oxide 31C4KY9ESH
Arginine 94ZLA3W45F
Nitric Oxide Synthase EC 1.14.13.39
Amidohydrolases EC 3.5.-
dimethylargininase EC 3.5.3.18

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116816

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Corey M Johnson (CM)

Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, TX 78712, USA; Department of Chemistry and Biochemistry, Howard College of Arts and Sciences, Samford University, Birmingham, AL 35229, USA.

Walter Fast (W)

Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, TX 78712, USA. Electronic address: walt.fast@austin.utexas.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › On the kinetic mechanism of dimethylarginine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Arginine › On the kinetic mechanism of dimethylarginine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › On the kinetic mechanism of dimethylarginine...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › On the kinetic mechanism of dimethylarginine...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › On the kinetic mechanism of dimethylarginine...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › On the kinetic mechanism of dimethylarginine...